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• W3022667659 abstract "The aging process eventually cause a breakdown in critical synaptic plasticity and connectivity leading to deficits in memory function. The olfactory bulb (OB) and the hippocampus, both regions of the brain considered critical for the processing of odors and spatial memory, are commonly affected by aging. Using an aged wild-type C57B/6 mouse model, we sought to define the effects of aging on hippocampal plasticity and the integrity of cortical circuits. Specifically, we measured the long-term potentiation of high-frequency stimulation (HFS-LTP) at the Shaffer-Collateral CA1 pyramidal synapses. Next, local field potential (LFP) spectra, phase-amplitude theta-gamma coupling (PAC), and connectivity through coherence were assessed in the olfactory bulb, frontal and entorhinal cortices, CA1, and amygdala circuits. The OB of aged mice showed a significant increase in the number of histone H2AX-positive neurons, a marker of DNA damage. While the input-output relationship measure of basal synaptic activity was found not to differ between young and aged mice, a pronounced decline in the slope of field excitatory postsynaptic potential (fEPSP) and the population spike amplitude (PSA) were found in aged mice. Furthermore, aging was accompanied by deficits in gamma network oscillations, a shift to slow oscillations, reduced coherence and theta-gamma PAC in the OB circuit. Thus, while the basal synaptic activity was unaltered in older mice, impairment in hippocampal synaptic transmission was observed only in response to HFS. However, age-dependent alterations in neural network appeared spontaneously in the OB circuit, suggesting the neurophysiological basis of synaptic deficits underlying olfactory processing. Taken together, the results highlight the sensitivity and therefore potential use of LFP quantitative network oscillations and connectivity at the OB level as objective electrophysiological markers that will help reveal specific dysfunctional circuits in aging-related neurodegeneration studies." @default.
• W3022667659 created "2020-05-13" @default.
• W3022667659 creator A5016583382 @default.
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• W3022667659 date "2020-05-02" @default.
• W3022667659 modified "2023-09-27" @default.
• W3022667659 title "Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies" @default.
• W3022667659 cites W1481984979 @default.
• W3022667659 cites W1518939040 @default.
• W3022667659 cites W1590824729 @default.
• W3022667659 cites W1817525470 @default.
• W3022667659 cites W1882519298 @default.
• W3022667659 cites W1963591499 @default.
• W3022667659 cites W1963638560 @default.
• W3022667659 cites W1964296044 @default.
• W3022667659 cites W1964310366 @default.
• W3022667659 cites W1966943727 @default.
• W3022667659 cites W1968711216 @default.
• W3022667659 cites W1969205548 @default.
• W3022667659 cites W1970836968 @default.
• W3022667659 cites W1972565866 @default.
• W3022667659 cites W1973311433 @default.
• W3022667659 cites W1975221291 @default.
• W3022667659 cites W1977177901 @default.
• W3022667659 cites W1978389345 @default.
• W3022667659 cites W1980138738 @default.
• W3022667659 cites W1983217609 @default.
• W3022667659 cites W1983488951 @default.
• W3022667659 cites W1983553517 @default.
• W3022667659 cites W1983949152 @default.
• W3022667659 cites W1984252627 @default.
• W3022667659 cites W1985842003 @default.
• W3022667659 cites W1988096519 @default.
• W3022667659 cites W1988099187 @default.
• W3022667659 cites W1993179764 @default.
• W3022667659 cites W1994670976 @default.
• W3022667659 cites W1997520206 @default.
• W3022667659 cites W1997679949 @default.
• W3022667659 cites W1999027550 @default.
• W3022667659 cites W2005253565 @default.
• W3022667659 cites W2006099430 @default.
• W3022667659 cites W2006723226 @default.
• W3022667659 cites W2015310369 @default.
• W3022667659 cites W2020680391 @default.
• W3022667659 cites W2021225760 @default.
• W3022667659 cites W2022732335 @default.
• W3022667659 cites W2023886341 @default.
• W3022667659 cites W2029421291 @default.
• W3022667659 cites W2033308797 @default.
• W3022667659 cites W2036855091 @default.
• W3022667659 cites W2041124923 @default.
• W3022667659 cites W2041699536 @default.
• W3022667659 cites W2043505681 @default.
• W3022667659 cites W2044289937 @default.
• W3022667659 cites W2046198005 @default.
• W3022667659 cites W2046557060 @default.
• W3022667659 cites W2053145106 @default.
• W3022667659 cites W2056336718 @default.
• W3022667659 cites W2057249855 @default.
• W3022667659 cites W2059940521 @default.
• W3022667659 cites W2062434441 @default.
• W3022667659 cites W2066464582 @default.
• W3022667659 cites W2071599468 @default.
• W3022667659 cites W2073186731 @default.
• W3022667659 cites W2074061123 @default.
• W3022667659 cites W2076472237 @default.
• W3022667659 cites W2077312000 @default.
• W3022667659 cites W2077491345 @default.
• W3022667659 cites W2078195513 @default.
• W3022667659 cites W2079403009 @default.
• W3022667659 cites W2083620176 @default.
• W3022667659 cites W2084792449 @default.
• W3022667659 cites W2086733715 @default.
• W3022667659 cites W2086900724 @default.
• W3022667659 cites W2087512314 @default.
• W3022667659 cites W2087819096 @default.
• W3022667659 cites W2091444488 @default.
• W3022667659 cites W2095429348 @default.
• W3022667659 cites W2095484045 @default.
• W3022667659 cites W2109542855 @default.
• W3022667659 cites W2114093008 @default.
• W3022667659 cites W2115483644 @default.
• W3022667659 cites W2115788675 @default.
• W3022667659 cites W2121981193 @default.
• W3022667659 cites W2127572254 @default.
• W3022667659 cites W2131367668 @default.
• W3022667659 cites W2135894974 @default.
• W3022667659 cites W2138623500 @default.
• W3022667659 cites W2141613743 @default.
• W3022667659 cites W2141954297 @default.
• W3022667659 cites W2149561999 @default.
• W3022667659 cites W2149991987 @default.
• W3022667659 cites W2154639805 @default.
• W3022667659 cites W2166160073 @default.
• W3022667659 cites W2169055490 @default.

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