Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022694986> ?p ?o ?g. }
- W3022694986 endingPage "133" @default.
- W3022694986 startingPage "126" @default.
- W3022694986 abstract "The novel small-molecule psychomotor stabilizer, IRL790, is currently in clinical trial for treatment of levodopa-induced dyskinesia and psychosis in patients with Parkinson disease. Here, we used naïve mice to investigate the effects of acute systemic administration of IRL790 on protein levels and phosphorylation states of proteins relevant for synaptic plasticity and transmission. IRL790 increased pro-brain-derived neurotrophic factor protein levels and phosphorylation at Ser1303 of the N-methyl-D-aspartate (NMDA) subtype 2B glutamate receptor (NR2B) in prefrontal cortex. IRL790 also increased the phosphorylation states at Ser19, Ser31, and Ser40, respectively, of tyrosine hydroxylase in striatum. IRL790 reduced protein levels of the NR2B receptor in striatum but not in prefrontal cortex. Taken together, we report that systemically administered IRL790 rapidly elicits changes in protein level and phosphorylation state of proteins associated with a beneficial effect on synaptic markers and neurotransmission. SIGNIFICANCE STATEMENT: The novel small-molecule psychomotor stabilizer, IRL790, is currently in clinical trial for treatment of levodopa-induced dyskinesia and psychosis in patients with Parkinson disease. In this study, we report that systemically administered IRL790 rapidly elicits changes in protein level and phosphorylation state of proteins associated with a beneficial effect on synaptic markers and neurotransmission." @default.
- W3022694986 created "2020-05-13" @default.
- W3022694986 creator A5014624169 @default.
- W3022694986 creator A5021723701 @default.
- W3022694986 creator A5036364090 @default.
- W3022694986 creator A5079216658 @default.
- W3022694986 creator A5087876357 @default.
- W3022694986 date "2020-05-01" @default.
- W3022694986 modified "2023-10-03" @default.
- W3022694986 title "Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission" @default.
- W3022694986 cites W1507452489 @default.
- W3022694986 cites W1543186331 @default.
- W3022694986 cites W1964127562 @default.
- W3022694986 cites W1967316112 @default.
- W3022694986 cites W1971263143 @default.
- W3022694986 cites W1980202815 @default.
- W3022694986 cites W1985464631 @default.
- W3022694986 cites W1990862724 @default.
- W3022694986 cites W1991856249 @default.
- W3022694986 cites W1996893328 @default.
- W3022694986 cites W2004019168 @default.
- W3022694986 cites W2013700933 @default.
- W3022694986 cites W2014845687 @default.
- W3022694986 cites W2024380057 @default.
- W3022694986 cites W2027603848 @default.
- W3022694986 cites W2037512822 @default.
- W3022694986 cites W2052841385 @default.
- W3022694986 cites W2053486952 @default.
- W3022694986 cites W2058543411 @default.
- W3022694986 cites W2062319694 @default.
- W3022694986 cites W2066110504 @default.
- W3022694986 cites W2066358338 @default.
- W3022694986 cites W2066386560 @default.
- W3022694986 cites W2077584190 @default.
- W3022694986 cites W2112559108 @default.
- W3022694986 cites W2114431124 @default.
- W3022694986 cites W2117062466 @default.
- W3022694986 cites W2140019166 @default.
- W3022694986 cites W2151986987 @default.
- W3022694986 cites W2165583726 @default.
- W3022694986 cites W2165909414 @default.
- W3022694986 cites W2566275194 @default.
- W3022694986 cites W2742071901 @default.
- W3022694986 cites W27428450 @default.
- W3022694986 cites W2902036449 @default.
- W3022694986 cites W3022343794 @default.
- W3022694986 cites W4319425454 @default.
- W3022694986 doi "https://doi.org/10.1124/jpet.119.264754" @default.
- W3022694986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32358047" @default.
- W3022694986 hasPublicationYear "2020" @default.
- W3022694986 type Work @default.
- W3022694986 sameAs 3022694986 @default.
- W3022694986 citedByCount "2" @default.
- W3022694986 countsByYear W30226949862021 @default.
- W3022694986 countsByYear W30226949862023 @default.
- W3022694986 crossrefType "journal-article" @default.
- W3022694986 hasAuthorship W3022694986A5014624169 @default.
- W3022694986 hasAuthorship W3022694986A5021723701 @default.
- W3022694986 hasAuthorship W3022694986A5036364090 @default.
- W3022694986 hasAuthorship W3022694986A5079216658 @default.
- W3022694986 hasAuthorship W3022694986A5087876357 @default.
- W3022694986 hasBestOaLocation W30226949861 @default.
- W3022694986 hasConcept C118552586 @default.
- W3022694986 hasConcept C11960822 @default.
- W3022694986 hasConcept C126322002 @default.
- W3022694986 hasConcept C15744967 @default.
- W3022694986 hasConcept C169760540 @default.
- W3022694986 hasConcept C169900460 @default.
- W3022694986 hasConcept C170493617 @default.
- W3022694986 hasConcept C200170125 @default.
- W3022694986 hasConcept C2779134260 @default.
- W3022694986 hasConcept C2779727114 @default.
- W3022694986 hasConcept C2779734285 @default.
- W3022694986 hasConcept C2780062018 @default.
- W3022694986 hasConcept C2780405171 @default.
- W3022694986 hasConcept C2781195155 @default.
- W3022694986 hasConcept C513476851 @default.
- W3022694986 hasConcept C61174792 @default.
- W3022694986 hasConcept C71924100 @default.
- W3022694986 hasConcept C86803240 @default.
- W3022694986 hasConcept C95444343 @default.
- W3022694986 hasConcept C98229152 @default.
- W3022694986 hasConcept C98274493 @default.
- W3022694986 hasConceptScore W3022694986C118552586 @default.
- W3022694986 hasConceptScore W3022694986C11960822 @default.
- W3022694986 hasConceptScore W3022694986C126322002 @default.
- W3022694986 hasConceptScore W3022694986C15744967 @default.
- W3022694986 hasConceptScore W3022694986C169760540 @default.
- W3022694986 hasConceptScore W3022694986C169900460 @default.
- W3022694986 hasConceptScore W3022694986C170493617 @default.
- W3022694986 hasConceptScore W3022694986C200170125 @default.
- W3022694986 hasConceptScore W3022694986C2779134260 @default.
- W3022694986 hasConceptScore W3022694986C2779727114 @default.
- W3022694986 hasConceptScore W3022694986C2779734285 @default.
- W3022694986 hasConceptScore W3022694986C2780062018 @default.
- W3022694986 hasConceptScore W3022694986C2780405171 @default.
- W3022694986 hasConceptScore W3022694986C2781195155 @default.
- W3022694986 hasConceptScore W3022694986C513476851 @default.