Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022696467> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3022696467 endingPage "166" @default.
- W3022696467 startingPage "157" @default.
- W3022696467 abstract "Alpha-2 agonists have sedative, analgesic, and opioid-sparing effects. Moreover, intraoperative or postoperative systemic administration of alpha-2 adrenergic agonists is known to reduce postoperative pain and opioid consumption. This meta-analysis investigated whether preoperative administration of alpha-2 agonists can affect postoperative pain and opioid consumption.We searched the MEDLINE, EMBASE, Cochrane Library (CENTRAL), KoreaMed, and KMbase databases through March 2019 to identify relevant randomized controlled trials (RCTs) on the effect of preoperative systemic administration of alpha-2 agonists on postoperative pain and opioid consumption. We conducted a meta-analysis according to the Cochrane Collaboration guidelines. Standardized mean differences (SMDs) of postoperative pain intensity or dose of opioid consumption in the alpha-2 agonist group were extracted and combined using a random-effect model and were compared to those of the control group.Eleven RCTs involving 748 participants were included in this meta-analysis. Preoperative administration of systemic alpha-2 agonists significantly reduced cumulative opioid consumption up to 6 h (SMD, -0.52; 95% confidence interval [-0.90 to -0.14]) and 24 h (SMD, -0.68 [-1.27 to -0.09]) after surgery. Moreover, preoperative administration of alpha-2 agonists significantly reduced postoperative pain intensity at 6 h (SMD, -0.50 [-0.78 to -0.21]) and 24 h (SMD, -0.44 [-0.86 to -0.03]).In this meta-analysis, high degree of heterogeneity limits the preoperative administration of alpha-2 agonists in reducing postoperative opioid consumption and pain intensity. Future powered large RCTs are required to increase the certainty of evidence on the effect in reducing postoperative opioid consumption and pain intensity." @default.
- W3022696467 created "2020-05-13" @default.
- W3022696467 creator A5003615379 @default.
- W3022696467 creator A5031611210 @default.
- W3022696467 creator A5073690426 @default.
- W3022696467 date "2020-04-30" @default.
- W3022696467 modified "2023-09-26" @default.
- W3022696467 title "Effect of preoperative administration of systemic alpha-2 agonists on postoperative pain: a systematic review and meta-analysis" @default.
- W3022696467 cites W1444168786 @default.
- W3022696467 cites W1527921597 @default.
- W3022696467 cites W1563527633 @default.
- W3022696467 cites W1851466778 @default.
- W3022696467 cites W192286927 @default.
- W3022696467 cites W1977674360 @default.
- W3022696467 cites W2028627441 @default.
- W3022696467 cites W2033323333 @default.
- W3022696467 cites W2034557139 @default.
- W3022696467 cites W2061208633 @default.
- W3022696467 cites W2068117630 @default.
- W3022696467 cites W2074753375 @default.
- W3022696467 cites W2080551366 @default.
- W3022696467 cites W2080745496 @default.
- W3022696467 cites W2099966451 @default.
- W3022696467 cites W2106843805 @default.
- W3022696467 cites W2123921747 @default.
- W3022696467 cites W2141857327 @default.
- W3022696467 cites W2156098321 @default.
- W3022696467 cites W2167561033 @default.
- W3022696467 cites W2415906046 @default.
- W3022696467 cites W2584710982 @default.
- W3022696467 cites W2781961011 @default.
- W3022696467 cites W2915066401 @default.
- W3022696467 cites W2991792334 @default.
- W3022696467 cites W78857293 @default.
- W3022696467 doi "https://doi.org/10.17085/apm.2020.15.2.157" @default.
- W3022696467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7713826" @default.
- W3022696467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33329808" @default.
- W3022696467 hasPublicationYear "2020" @default.
- W3022696467 type Work @default.
- W3022696467 sameAs 3022696467 @default.
- W3022696467 citedByCount "4" @default.
- W3022696467 countsByYear W30226964672021 @default.
- W3022696467 countsByYear W30226964672022 @default.
- W3022696467 countsByYear W30226964672023 @default.
- W3022696467 crossrefType "journal-article" @default.
- W3022696467 hasAuthorship W3022696467A5003615379 @default.
- W3022696467 hasAuthorship W3022696467A5031611210 @default.
- W3022696467 hasAuthorship W3022696467A5073690426 @default.
- W3022696467 hasBestOaLocation W30226964671 @default.
- W3022696467 hasConcept C126322002 @default.
- W3022696467 hasConcept C168563851 @default.
- W3022696467 hasConcept C170493617 @default.
- W3022696467 hasConcept C2776478404 @default.
- W3022696467 hasConcept C2780820201 @default.
- W3022696467 hasConcept C2781063702 @default.
- W3022696467 hasConcept C42219234 @default.
- W3022696467 hasConcept C44249647 @default.
- W3022696467 hasConcept C71924100 @default.
- W3022696467 hasConcept C95190672 @default.
- W3022696467 hasConceptScore W3022696467C126322002 @default.
- W3022696467 hasConceptScore W3022696467C168563851 @default.
- W3022696467 hasConceptScore W3022696467C170493617 @default.
- W3022696467 hasConceptScore W3022696467C2776478404 @default.
- W3022696467 hasConceptScore W3022696467C2780820201 @default.
- W3022696467 hasConceptScore W3022696467C2781063702 @default.
- W3022696467 hasConceptScore W3022696467C42219234 @default.
- W3022696467 hasConceptScore W3022696467C44249647 @default.
- W3022696467 hasConceptScore W3022696467C71924100 @default.
- W3022696467 hasConceptScore W3022696467C95190672 @default.
- W3022696467 hasIssue "2" @default.
- W3022696467 hasLocation W30226964671 @default.
- W3022696467 hasLocation W30226964672 @default.
- W3022696467 hasLocation W30226964673 @default.
- W3022696467 hasOpenAccess W3022696467 @default.
- W3022696467 hasPrimaryLocation W30226964671 @default.
- W3022696467 hasRelatedWork W2094000083 @default.
- W3022696467 hasRelatedWork W2328387903 @default.
- W3022696467 hasRelatedWork W2381982637 @default.
- W3022696467 hasRelatedWork W2393508812 @default.
- W3022696467 hasRelatedWork W2531052508 @default.
- W3022696467 hasRelatedWork W2748167152 @default.
- W3022696467 hasRelatedWork W2914141471 @default.
- W3022696467 hasRelatedWork W3029323012 @default.
- W3022696467 hasRelatedWork W3036326648 @default.
- W3022696467 hasRelatedWork W3132173363 @default.
- W3022696467 hasVolume "15" @default.
- W3022696467 isParatext "false" @default.
- W3022696467 isRetracted "false" @default.
- W3022696467 magId "3022696467" @default.
- W3022696467 workType "article" @default.