Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022710891> ?p ?o ?g. }
- W3022710891 endingPage "110862" @default.
- W3022710891 startingPage "110862" @default.
- W3022710891 abstract "G protein-coupled receptors (GPCRs) are highly conserved versatile signaling molecules located at the plasma membrane that respond to diverse extracellular signals. They regulate almost all physiological processes in the vertebrates. About 35% of current drugs target these receptors. Mutations in these genes have been identified as causes of numerous diseases. The seven transmembrane domain structure of GPCRs implies that the folding of these transmembrane proteins is extremely complicated and difficult. Indeed, many wild type GPCRs are not folded optimally. The most common defect in genetic diseases caused by GPCR mutations is misfolding and failure to reach the plasma membrane where it functions. General molecular chaperones aid the folding of all proteins, including GPCRs, by preventing aggregation, promoting folding and disaggregating small aggregates. Some GPCRs need additional receptor-specific chaperones to assist their folding. Many of these receptor-specific chaperones interact with additional receptors and alter receptor pharmacology, expanding the understanding of these chaperone proteins." @default.
- W3022710891 created "2020-05-13" @default.
- W3022710891 creator A5073594825 @default.
- W3022710891 date "2020-07-01" @default.
- W3022710891 modified "2023-10-16" @default.
- W3022710891 title "Molecular chaperones and G protein-coupled receptor maturation and pharmacology" @default.
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