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- W3022729884 abstract "Although nanoscaled metal–organic frameworks (nanoMOFs) are promising drug carriers, their appropriate formulation remains almost unexplored and basically restricted to intravenous routes. Lungs, beneficiating from a large absorption surface and low enzymatic presence, are a very attractive target for both local and systemic delivery. However, pulmonary nanoMOF formulation is a pending and defying task. Thus, we propose a pioneer nanoMOF-based microsphere system as a potential platform for pulmonary administration. A biocompatible nanoMOF was successfully encapsulated in mannitol by a simple and continuous spray-drying technique. Upon intratracheal administration to rats, the resulting formulation, exhibiting optimal properties (i.e., homogeneity, size, density, and spray-drying process yield), was able to release the intact nanoMOF carrier uniformly along the lungs, reaching the bronchioles and alveoli." @default.
- W3022729884 created "2020-05-13" @default.
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- W3022729884 date "2020-05-04" @default.
- W3022729884 modified "2023-10-17" @default.
- W3022729884 title "Metal–Organic Framework Microsphere Formulation for Pulmonary Administration" @default.
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- W3022729884 doi "https://doi.org/10.1021/acsami.0c07356" @default.
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