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- W3022731644 abstract "Objective: To investigate the different inhibition effects of different using sequential of microtubule depolymerization drug and polymerization drug on tumor cells.Methods: Three tumor cell lines including MCF-7、SK-OV3、A549 were incubated with paclitaxel(PTX) and /or vinorelbine(NVB) of different concentrations.The cytotoxicity was examined by MTT test after incubation 72 hours.According to different drugs and different sequences added to 96-well tissue culture plates,5 groups were divided: PTX group(Group 1),NVB group(Group 2),PTX plus NVB group(Group 3),PTX first and plus NVB 4-hours-later group(Group 4),NVB first and plus PTX 4-hour-later group(Group 5).Drug concentrations were 100% peak plasma concentration(PPC),50%PPC,25%PPC,12.5%PPC,and 6.25%PPC.Results: The inhibition effect on the three tumor cell lines in Group 5 was stronger than those in the other four groups(P0.01).And the inhibition effect in Group 4 was not stronger than those in Group 1,Group 2 or Group 3(P0.1).Conclusion: Using microtubule depolymerization drug first and then using microtubule polymerization drug have synergic inhibition effect on tumor cells." @default.
- W3022731644 created "2020-05-13" @default.
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- W3022731644 date "2008-01-01" @default.
- W3022731644 modified "2023-09-28" @default.
- W3022731644 title "Inhibition Effect of Using Sequential Microtubule Depolymerization Drug and Polymerization Drug on Tumor Cells" @default.
- W3022731644 hasPublicationYear "2008" @default.
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