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- W3022740971 abstract "Escalating problems with drug resistance continue to compromise the effectiveness of commercial antibiotics, necessitating the search for novel classes of antimicrobial agents. To circumvent problems with resistance, a multitarget single-pharmacophore approach has been employed to discover inhibitors that possess balanced activity against multiple target enzymes. In this chapter, we examine the application of computational techniques, in particular, structure-based drug design approaches, to design new dual-targeting antibacterial agents against bacterial topoisomerases." @default.
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- W3022740971 date "2011-03-18" @default.
- W3022740971 modified "2023-10-14" @default.
- W3022740971 title "Leveraging Structural Information for the Discovery of New Drugs - Computational Methods" @default.
- W3022740971 hasPublicationYear "2011" @default.
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