Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022753530> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3022753530 abstract "Basal markers [cytokeratin 5/6 (CK5/6) and epidermal growth factor receptor (EGFR)] are used in identifying the basal-like breast carcinoma subtype, which is associated with a poor prognosis. However, the clinicopathological significance in early-stage invasive carcinoma of no special type (IC, NST) has not been well established.In a five-year period, 133 female patients with early-stage IC, NST with a median follow-up time of 89 months were included. The immunohistochemistry-based molecular subtypes were identified according to ASCO/CAP guidelines in 2013. The cutoff values for basal positivity were determined as 10% for each marker.Basal positivity was recorded in 83.3% (5/6) of triple-negative breast cancers, 50% (2/4) of HER2-enriched, 18.6% (13/70) of luminal B, and 8.3% of luminal A (4/48) subtype. CK5/6 and EGFR positivity were significantly associated with ER negativity (p < 0.001). EGFR positive cases were significantly associated with PR negativity and HER2 positivity compared to negative cases. However, basal positivity was not associated with the patient outcome (p = 0.006 and p = 0.004, respectively).Basal positive IC, NSTs were associated with hormone receptor negativity and HER2 overexpression; these patients would therefore be less likely to respond to hormonotherapy and more likely to benefit from anti-HER2 treatment as well as dual-kinase inhibitors. The lack of standardization of the definition of basal marker positivity may contribute to the conflicting results of prognostic studies. Hence, further studies focusing on developing a standard protocol for determining basal marker positivity are needed not only for IC, NST but also for other histological types of breast cancer." @default.
- W3022753530 created "2020-05-13" @default.
- W3022753530 creator A5033831586 @default.
- W3022753530 creator A5058001283 @default.
- W3022753530 creator A5062271159 @default.
- W3022753530 creator A5088327951 @default.
- W3022753530 date "2020-01-01" @default.
- W3022753530 modified "2023-10-04" @default.
- W3022753530 title "The clinicopathological significance of basal markers in early-stage invasive carcinoma of no special type of the breast" @default.
- W3022753530 cites W1773938361 @default.
- W3022753530 cites W1963836449 @default.
- W3022753530 cites W1968617875 @default.
- W3022753530 cites W1974570521 @default.
- W3022753530 cites W1976279830 @default.
- W3022753530 cites W2042834596 @default.
- W3022753530 cites W2044702943 @default.
- W3022753530 cites W2081625464 @default.
- W3022753530 cites W2085880972 @default.
- W3022753530 cites W2099335989 @default.
- W3022753530 cites W2099645587 @default.
- W3022753530 cites W2101689123 @default.
- W3022753530 cites W2102596641 @default.
- W3022753530 cites W2107616793 @default.
- W3022753530 cites W2112377187 @default.
- W3022753530 cites W2115007832 @default.
- W3022753530 cites W2118083160 @default.
- W3022753530 cites W2131994307 @default.
- W3022753530 cites W2137853125 @default.
- W3022753530 cites W2142326174 @default.
- W3022753530 cites W2142709970 @default.
- W3022753530 cites W2144535237 @default.
- W3022753530 cites W2157430222 @default.
- W3022753530 cites W2161792005 @default.
- W3022753530 cites W2200149214 @default.
- W3022753530 cites W2332230038 @default.
- W3022753530 cites W42301152 @default.
- W3022753530 doi "https://doi.org/10.5146/tjpath.2020.01487" @default.
- W3022753530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32364614" @default.
- W3022753530 hasPublicationYear "2020" @default.
- W3022753530 type Work @default.
- W3022753530 sameAs 3022753530 @default.
- W3022753530 citedByCount "0" @default.
- W3022753530 crossrefType "journal-article" @default.
- W3022753530 hasAuthorship W3022753530A5033831586 @default.
- W3022753530 hasAuthorship W3022753530A5058001283 @default.
- W3022753530 hasAuthorship W3022753530A5062271159 @default.
- W3022753530 hasAuthorship W3022753530A5088327951 @default.
- W3022753530 hasBestOaLocation W30227535301 @default.
- W3022753530 hasConcept C121608353 @default.
- W3022753530 hasConcept C126322002 @default.
- W3022753530 hasConcept C142724271 @default.
- W3022753530 hasConcept C143998085 @default.
- W3022753530 hasConcept C146357865 @default.
- W3022753530 hasConcept C151730666 @default.
- W3022753530 hasConcept C204232928 @default.
- W3022753530 hasConcept C2778024521 @default.
- W3022753530 hasConcept C2779012181 @default.
- W3022753530 hasConcept C2779306644 @default.
- W3022753530 hasConcept C2779438470 @default.
- W3022753530 hasConcept C3018521938 @default.
- W3022753530 hasConcept C530470458 @default.
- W3022753530 hasConcept C71924100 @default.
- W3022753530 hasConcept C84606932 @default.
- W3022753530 hasConcept C86803240 @default.
- W3022753530 hasConcept C98717036 @default.
- W3022753530 hasConceptScore W3022753530C121608353 @default.
- W3022753530 hasConceptScore W3022753530C126322002 @default.
- W3022753530 hasConceptScore W3022753530C142724271 @default.
- W3022753530 hasConceptScore W3022753530C143998085 @default.
- W3022753530 hasConceptScore W3022753530C146357865 @default.
- W3022753530 hasConceptScore W3022753530C151730666 @default.
- W3022753530 hasConceptScore W3022753530C204232928 @default.
- W3022753530 hasConceptScore W3022753530C2778024521 @default.
- W3022753530 hasConceptScore W3022753530C2779012181 @default.
- W3022753530 hasConceptScore W3022753530C2779306644 @default.
- W3022753530 hasConceptScore W3022753530C2779438470 @default.
- W3022753530 hasConceptScore W3022753530C3018521938 @default.
- W3022753530 hasConceptScore W3022753530C530470458 @default.
- W3022753530 hasConceptScore W3022753530C71924100 @default.
- W3022753530 hasConceptScore W3022753530C84606932 @default.
- W3022753530 hasConceptScore W3022753530C86803240 @default.
- W3022753530 hasConceptScore W3022753530C98717036 @default.
- W3022753530 hasLocation W30227535301 @default.
- W3022753530 hasLocation W30227535302 @default.
- W3022753530 hasOpenAccess W3022753530 @default.
- W3022753530 hasPrimaryLocation W30227535301 @default.
- W3022753530 hasRelatedWork W1480735458 @default.
- W3022753530 hasRelatedWork W150275630 @default.
- W3022753530 hasRelatedWork W1992261227 @default.
- W3022753530 hasRelatedWork W202920663 @default.
- W3022753530 hasRelatedWork W2029559096 @default.
- W3022753530 hasRelatedWork W2037309347 @default.
- W3022753530 hasRelatedWork W2088783977 @default.
- W3022753530 hasRelatedWork W2106006593 @default.
- W3022753530 hasRelatedWork W2346103388 @default.
- W3022753530 hasRelatedWork W3138581044 @default.
- W3022753530 isParatext "false" @default.
- W3022753530 isRetracted "false" @default.
- W3022753530 magId "3022753530" @default.
- W3022753530 workType "article" @default.