Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022758411> ?p ?o ?g. }
- W3022758411 endingPage "1531" @default.
- W3022758411 startingPage "1511" @default.
- W3022758411 abstract "Osteogenesis imperfecta (OI) is a highly variable heritable disease of bone characterized by recurring bone fractures. It is the most common single gene defect causing bone disease. Three degrees of deforming OI, types II, III, and IV, are associated with decreasing severity of growth retardation and limb deformity and all result from a mutation affecting the structure of the type 1 collagen molecule. This chapter provides an update to the well-described clinical classifications and points out recent advances in the diagnosis and therapy of the disease. It also reviews the consequences of mutations of type 1 collagen on the structure of the collagen fibers. Following this, it explains the biology of the osteoblast. Based on the understanding of the biology, it establishes the pathophysiology of the resulting bone disease. Furthermore, it emphasizes how this information influences the understanding of osteoporosis and other heritable diseases of connective tissue. In addition, it presents outstanding problems requiring further research attention, particularly relating to cell and somatic gene therapy. Finally, it discusses the therapy of OI using anti-resorptive agents." @default.
- W3022758411 created "2020-05-13" @default.
- W3022758411 creator A5067453135 @default.
- W3022758411 date "2008-01-01" @default.
- W3022758411 modified "2023-10-12" @default.
- W3022758411 title "Osteogenesis Imperfecta" @default.
- W3022758411 cites W140131225 @default.
- W3022758411 cites W1487533640 @default.
- W3022758411 cites W1521308319 @default.
- W3022758411 cites W1534731743 @default.
- W3022758411 cites W1587602433 @default.
- W3022758411 cites W1589868959 @default.
- W3022758411 cites W1598319236 @default.
- W3022758411 cites W163722498 @default.
- W3022758411 cites W170408623 @default.
- W3022758411 cites W1817730719 @default.
- W3022758411 cites W191971915 @default.
- W3022758411 cites W1930718057 @default.
- W3022758411 cites W1964939337 @default.
- W3022758411 cites W1965008138 @default.
- W3022758411 cites W1965078322 @default.
- W3022758411 cites W1965986355 @default.
- W3022758411 cites W1966470127 @default.
- W3022758411 cites W1967241081 @default.
- W3022758411 cites W1967695449 @default.
- W3022758411 cites W1968569170 @default.
- W3022758411 cites W1968882957 @default.
- W3022758411 cites W1969051840 @default.
- W3022758411 cites W1970057036 @default.
- W3022758411 cites W1970577029 @default.
- W3022758411 cites W1974405618 @default.
- W3022758411 cites W1974586799 @default.
- W3022758411 cites W1975084324 @default.
- W3022758411 cites W1976818385 @default.
- W3022758411 cites W1977188016 @default.
- W3022758411 cites W1977951739 @default.
- W3022758411 cites W1978028697 @default.
- W3022758411 cites W1978162436 @default.
- W3022758411 cites W1978548785 @default.
- W3022758411 cites W1979670319 @default.
- W3022758411 cites W1979814760 @default.
- W3022758411 cites W1980119297 @default.
- W3022758411 cites W1980139196 @default.
- W3022758411 cites W1982444756 @default.
- W3022758411 cites W1982548794 @default.
- W3022758411 cites W1982956225 @default.
- W3022758411 cites W1983256487 @default.
- W3022758411 cites W1984027634 @default.
- W3022758411 cites W1986029912 @default.
- W3022758411 cites W1986037422 @default.
- W3022758411 cites W1986364669 @default.
- W3022758411 cites W1986457784 @default.
- W3022758411 cites W1986848527 @default.
- W3022758411 cites W1987239565 @default.
- W3022758411 cites W1987634799 @default.
- W3022758411 cites W1987869274 @default.
- W3022758411 cites W1988181313 @default.
- W3022758411 cites W1988436331 @default.
- W3022758411 cites W1989885963 @default.
- W3022758411 cites W1990259874 @default.
- W3022758411 cites W1990336718 @default.
- W3022758411 cites W1990858798 @default.
- W3022758411 cites W1990894610 @default.
- W3022758411 cites W1991350431 @default.
- W3022758411 cites W1991453189 @default.
- W3022758411 cites W1991628111 @default.
- W3022758411 cites W1991630907 @default.
- W3022758411 cites W1992687573 @default.
- W3022758411 cites W1992948544 @default.
- W3022758411 cites W1993609715 @default.
- W3022758411 cites W1994422325 @default.
- W3022758411 cites W1994827328 @default.
- W3022758411 cites W1995192760 @default.
- W3022758411 cites W1995869907 @default.
- W3022758411 cites W1996133970 @default.
- W3022758411 cites W1996437793 @default.
- W3022758411 cites W1998446404 @default.
- W3022758411 cites W1998912498 @default.
- W3022758411 cites W2000509303 @default.
- W3022758411 cites W2000944641 @default.
- W3022758411 cites W2001741437 @default.
- W3022758411 cites W2002100378 @default.
- W3022758411 cites W2007055861 @default.
- W3022758411 cites W2007453543 @default.
- W3022758411 cites W2008680085 @default.
- W3022758411 cites W2011119990 @default.
- W3022758411 cites W2011610305 @default.
- W3022758411 cites W2013870689 @default.
- W3022758411 cites W2014209332 @default.
- W3022758411 cites W2014495070 @default.
- W3022758411 cites W2015022545 @default.
- W3022758411 cites W2015318817 @default.
- W3022758411 cites W2015454850 @default.
- W3022758411 cites W2015669374 @default.
- W3022758411 cites W2018151480 @default.
- W3022758411 cites W2018549462 @default.
- W3022758411 cites W2018853396 @default.
- W3022758411 cites W2018868266 @default.