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- W3022758946 abstract "The conversion from Mild Cognitive Impairment (MCI) to dementia has received considerable research attention, whereas the transition from normal cognition to MCI and dementia in an autopsy-confirmed case of Alzheimer disease (AD) has not been studied in detail. We studied the conversion from normal memory and cognition to MCI of the amnestic type to early dementia with annual assessments over 10 years using a comprehensive neuropsychological test battery in a neuropathologically-confirmed case of AD. The woman was 74 years old at the first evaluation and was 84 years old at the time of her last assessment. She was a retired high school teacher with 18 years of education. An annual half-day cognitive assessment was administered to the patient including tests of mental status, attention, new learning and memory, language, visuospatial functioning, and problem solving ability. The patient scored well within normal limits on all memory and cognitive test measures using age norms at her first evaluation (age 74). A gradual progressive decline over ten years on measures of new declarative learning and memory, especially on word-list learning tests, was found resulting in severe memory impairment at age 78. Only later did measurable decline on the non-memory cognitive measures emerge. Neuropathological findings at autopsy revealed Alzheimer-type changes that indicated a high likelihood, by NIA-Reagan criteria, that the dementia was due to Alzheimer disease. There was moderate CERAD plaque grade and Braak and Braak tangle stage V. There was a heavy NFT and NP burden in the hippocampus, entorhinal cortex, perirhinal cortex, and amygdala, a moderate number in the inferior temporal gyrus with less Alzheimer pathology burden in the frontal, parietal, and occipital cortices and the superior temporal gyrus. Progressive memory decline in an autopsy-confirmed case of AD occurred gradually over 7–8 years before there is detectable non-memory cognitive deficits emerged on a comprehensive neuropsychological battery of tests. This case is likely representative of many, but not all, cases of AD." @default.
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- W3022758946 date "2007-07-01" @default.
- W3022758946 modified "2023-09-27" @default.
- W3022758946 title "P-138: An autopsy-confirmed case study of the conversion from normal cognition to amnestic MCI to AD" @default.
- W3022758946 doi "https://doi.org/10.1016/j.jalz.2007.04.202" @default.
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