Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022772535> ?p ?o ?g. }
- W3022772535 endingPage "646" @default.
- W3022772535 startingPage "646" @default.
- W3022772535 abstract "Neutropenic sepsis is a fatal consequence of chemotherapy, and septic complications are the principal cause of mortality. Chemotherapy-induced neutropenia leads to the formation of microscopic ulcers in the gastrointestinal epithelium that function as a portal of entry for intraluminal bacteria, which translocate across the intestinal mucosal barrier and gain access to systemic sites, causing septicemia. A cyclophosphamide-induced mouse model was developed to mimic the pathophysiologic sequence of events that occurs in patients with neutropenic sepsis. The TLR5 agonist bacterial flagellin derived from Vibrio vulnificus extended the survival of cyclophosphamide-treated mice by reducing the bacterial load in internal organs. The protective effect of flagellin was mediated by the antimicrobial protein lipocalin 2 (Lcn2), which is induced by TLR5-NF-κB activation in hepatocytes. Lcn2 sequestered iron from infecting bacteria, particularly siderophore enterobactin-dependent members of the Enterobacteriaceae family, thereby limiting their proliferation. Lcn2 should be considered for the treatment of neutropenic sepsis and gastrointestinal damage during chemotherapy to prevent or minimize the adverse effects of cancer chemotherapy." @default.
- W3022772535 created "2020-05-13" @default.
- W3022772535 creator A5012131421 @default.
- W3022772535 creator A5013222112 @default.
- W3022772535 creator A5018557878 @default.
- W3022772535 creator A5020726281 @default.
- W3022772535 creator A5020931102 @default.
- W3022772535 creator A5021717111 @default.
- W3022772535 creator A5024138203 @default.
- W3022772535 creator A5036941709 @default.
- W3022772535 creator A5040222459 @default.
- W3022772535 creator A5045334638 @default.
- W3022772535 creator A5060429660 @default.
- W3022772535 creator A5063610465 @default.
- W3022772535 creator A5079004842 @default.
- W3022772535 date "2020-04-29" @default.
- W3022772535 modified "2023-10-16" @default.
- W3022772535 title "Lipocalin2 Induced by Bacterial Flagellin Protects Mice against Cyclophosphamide Mediated Neutropenic Sepsis" @default.
- W3022772535 cites W1519633296 @default.
- W3022772535 cites W1552658552 @default.
- W3022772535 cites W1604783437 @default.
- W3022772535 cites W16428338 @default.
- W3022772535 cites W1872693321 @default.
- W3022772535 cites W1880766193 @default.
- W3022772535 cites W1966625479 @default.
- W3022772535 cites W1973938903 @default.
- W3022772535 cites W1988197452 @default.
- W3022772535 cites W1988579689 @default.
- W3022772535 cites W1991303877 @default.
- W3022772535 cites W1998794592 @default.
- W3022772535 cites W2014243721 @default.
- W3022772535 cites W2016279011 @default.
- W3022772535 cites W2017487826 @default.
- W3022772535 cites W2018011543 @default.
- W3022772535 cites W2018627170 @default.
- W3022772535 cites W2018683379 @default.
- W3022772535 cites W20230162 @default.
- W3022772535 cites W2036124167 @default.
- W3022772535 cites W2046486151 @default.
- W3022772535 cites W2048093113 @default.
- W3022772535 cites W2048576319 @default.
- W3022772535 cites W2050490859 @default.
- W3022772535 cites W2050669419 @default.
- W3022772535 cites W2054034736 @default.
- W3022772535 cites W2056148624 @default.
- W3022772535 cites W2057858743 @default.
- W3022772535 cites W2058091604 @default.
- W3022772535 cites W2060973508 @default.
- W3022772535 cites W2074692187 @default.
- W3022772535 cites W2084227342 @default.
- W3022772535 cites W2101363646 @default.
- W3022772535 cites W2121443809 @default.
- W3022772535 cites W2122335736 @default.
- W3022772535 cites W2124351063 @default.
- W3022772535 cites W2127303481 @default.
- W3022772535 cites W2131271579 @default.
- W3022772535 cites W2136879569 @default.
- W3022772535 cites W2138122982 @default.
- W3022772535 cites W2143589922 @default.
- W3022772535 cites W2152278126 @default.
- W3022772535 cites W2154786756 @default.
- W3022772535 cites W2169203358 @default.
- W3022772535 cites W2312090439 @default.
- W3022772535 cites W2509124354 @default.
- W3022772535 cites W2567712538 @default.
- W3022772535 cites W2579533542 @default.
- W3022772535 cites W2586223583 @default.
- W3022772535 cites W2796501734 @default.
- W3022772535 cites W2964200492 @default.
- W3022772535 doi "https://doi.org/10.3390/microorganisms8050646" @default.
- W3022772535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7284693" @default.
- W3022772535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32365611" @default.
- W3022772535 hasPublicationYear "2020" @default.
- W3022772535 type Work @default.
- W3022772535 sameAs 3022772535 @default.
- W3022772535 citedByCount "4" @default.
- W3022772535 countsByYear W30227725352021 @default.
- W3022772535 countsByYear W30227725352022 @default.
- W3022772535 countsByYear W30227725352023 @default.
- W3022772535 crossrefType "journal-article" @default.
- W3022772535 hasAuthorship W3022772535A5012131421 @default.
- W3022772535 hasAuthorship W3022772535A5013222112 @default.
- W3022772535 hasAuthorship W3022772535A5018557878 @default.
- W3022772535 hasAuthorship W3022772535A5020726281 @default.
- W3022772535 hasAuthorship W3022772535A5020931102 @default.
- W3022772535 hasAuthorship W3022772535A5021717111 @default.
- W3022772535 hasAuthorship W3022772535A5024138203 @default.
- W3022772535 hasAuthorship W3022772535A5036941709 @default.
- W3022772535 hasAuthorship W3022772535A5040222459 @default.
- W3022772535 hasAuthorship W3022772535A5045334638 @default.
- W3022772535 hasAuthorship W3022772535A5060429660 @default.
- W3022772535 hasAuthorship W3022772535A5063610465 @default.
- W3022772535 hasAuthorship W3022772535A5079004842 @default.
- W3022772535 hasBestOaLocation W30227725351 @default.
- W3022772535 hasConcept C126322002 @default.
- W3022772535 hasConcept C170493617 @default.
- W3022772535 hasConcept C203014093 @default.
- W3022772535 hasConcept C2776070231 @default.