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• W3022788281 abstract "Individual epithelial tumor cells disseminated to mesenchymal organs early during primary tumor development can now be identified with monoclonal antibodies directed to cytokeratins as obligatory constituents of the epithelial cytoskeleton (for review see Pantel and Riethmüller, this volume) Among the various organs investigated bone marrow appears to play a prominent role as indicator organ of such micrometastatic spread. Bone marrow is an easily accessible organ which normally lacks any epithelial cells. Thus, consecutive marrow samples can be taken from individual patients and “foreign” epithelial cells can be easily detected by use of anti-cytokeratin monoclonal antibodies. Moreover, bone or bone marrow is one of the major sites of skeletal metastasis in several types of epithelial tumors, including cancer of the breast, prostate or lung." @default.
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• W3022788281 date "1996-01-01" @default.
• W3022788281 modified "2023-09-24" @default.
• W3022788281 title "Biological Characteristics of Micrometastatic Carcinoma Cells in Bone Marrow" @default.
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• W3022788281 doi "https://doi.org/10.1007/978-3-642-61107-0_10" @default.
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