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• W3022789705 abstract "This study presents the fabrication of three-dimensional (3D) microelectrodes for subretinal stimulation, to accommodate adjacent return electrodes surrounding a stimulating electrode. For retinal prosthetic devices, the arrangement of return electrodes, the electrode size and spacing should be considered together, to reduce the undesired dissipation of electric currents. Here, we applied the hexagonal arrangement to the microelectrode array for the localized activation of retinal cells and better visual acuity. To provide stimuli more efficiently to non-spiking neurons, a 3D structure was created through a customized pressing process, utilizing the elastic property of the materials used in the fabrication processes. The diameter and pitch of the Pt-coated electrodes were 150 μm and 350 μm, respectively, and the height of the protruded electrodes was around 20 μm. The array consisted of 98 hexagonally arranged electrodes, supported by a flexible and transparent polydimethylsiloxane (PDMS) base, with a thickness of 140 μm. Also, the array was coated with 2 μm-thick parylene-C, except the active electrode sites, for more focused stimulation. Finally, the electrochemical properties of the fabricated microelectrodes were characterized, resulting in the mean impedance of 384.87 kΩ at 1 kHz and the charge storage capacity (CSC) of 2.83 mC·cm−2. The fabricated microelectrodes are to be combined with an integrated circuit (IC) for additional in vitro and in vivo experiments." @default.
• W3022789705 created "2020-05-13" @default.
• W3022789705 creator A5010040405 @default.
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• W3022789705 date "2020-04-29" @default.
• W3022789705 modified "2023-09-26" @default.
• W3022789705 title "Fabrication of Subretinal 3D Microelectrodes with Hexagonal Arrangement" @default.
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• W3022789705 doi "https://doi.org/10.3390/mi11050467" @default.
• W3022789705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7281732" @default.
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• W3022789705 hasPublicationYear "2020" @default.
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