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- W3022794609 abstract "This chapter focuses on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and the seronegative spondyloarthropathies, which include ankylosing spondylitis (AS), reactive arthritis, the arthritis of inflammatory bowel disease, juvenile-onset spondyloarthropathy, and psoriatic arthritis. Four major forms of pathologic skeletal remodeling can be observed in RA, including focal marginal articular erosions, subchondral bone loss, periarticular osteopenia, and systemic osteoporosis. AS is characterized by inflammation in the entheses, as well as the synovial lining of peripheral joints. Examination of the synovial lesion reveals many of the same features as the RA synovium, including synovial lining hyperplasia, lymphocytic infiltration and pannus formation. In contrast to the pattern of articular bone remodeling in RA, in patients with AS, the inflammatory process may be accompanied by evidence of increased bone formation. SLE, similar to RA, is a systemic inflammatory disease, which, in addition to targeting joint structures, may be associated with widespread extra-articular organ damage." @default.
- W3022794609 created "2020-05-13" @default.
- W3022794609 creator A5080984126 @default.
- W3022794609 date "2013-07-19" @default.
- W3022794609 modified "2023-10-10" @default.
- W3022794609 title "Inflammation-Induced Bone Loss in the Rheumatic Diseases" @default.
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- W3022794609 doi "https://doi.org/10.1002/9781118453926.ch59" @default.
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