Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022805972> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3022805972 abstract "Background. Multiple sclerosis (MS) is a chronic disease characterized by loss of myelin. However, data indicate that autoimmune cells could directly impair neuronal cell bodies and myelin sheath is lacking. The aim of the present study was to determine morphological evidence of the direct impairment of neurons by autoreactive lymphocytes and to further identify the subtypes of these lymphocytes. Methods. Lymphocytes activated by myelin basic protein (MBP) 83e99 and neurons of human brain were co-cultured for 24 h. Results. Observations through scanning electron microscope showed that MBP-specific lymphocytes (CD4þ, CD8þ cells, and NK cells) aggregated in the vicinity of the neuronal cell bodies and the myelin sheaths and attacked them directly, resulting in the degeneration of both neurons. Conclusions. Our studies provide morphological evidences of the direct impairment of neuronal cell bodies and myelin sheaths by MBP-specific lymphocytes. Our studies also suggest that MBP-specific CD4þ, CD8þ, and NK cells might be involved in this process. These processes may play a role in the direct impairment of neurons and myelin sheaths in early stages of MS and provide evidences for the application of immunosuppressant therapy of MS. 2008 IMSS. Published by Elsevier Inc." @default.
- W3022805972 created "2020-05-13" @default.
- W3022805972 creator A5004116275 @default.
- W3022805972 creator A5015609876 @default.
- W3022805972 creator A5037519871 @default.
- W3022805972 creator A5050940474 @default.
- W3022805972 creator A5071781931 @default.
- W3022805972 creator A5081444133 @default.
- W3022805972 date "2008-01-01" @default.
- W3022805972 modified "2023-09-23" @default.
- W3022805972 title "Myelin-Basic Protein-reactive Specific CD4 þ and CD8 þ NK Lymphocytes Induce Morphological Changes in Neuronal Cell Bodies and Myelin Sheaths: Implications for Multiple Sclerosis" @default.
- W3022805972 cites W1544302889 @default.
- W3022805972 cites W1937650001 @default.
- W3022805972 cites W1946323404 @default.
- W3022805972 cites W1978515072 @default.
- W3022805972 cites W1990640592 @default.
- W3022805972 cites W2031448778 @default.
- W3022805972 cites W2034860726 @default.
- W3022805972 cites W2038269384 @default.
- W3022805972 cites W2043761833 @default.
- W3022805972 cites W2061891340 @default.
- W3022805972 cites W2070886120 @default.
- W3022805972 cites W2070978390 @default.
- W3022805972 cites W2096682840 @default.
- W3022805972 cites W2117659036 @default.
- W3022805972 cites W2122347714 @default.
- W3022805972 cites W2122718589 @default.
- W3022805972 cites W2136325849 @default.
- W3022805972 cites W2166507237 @default.
- W3022805972 cites W2171397519 @default.
- W3022805972 cites W2219979042 @default.
- W3022805972 cites W2349896321 @default.
- W3022805972 cites W2018782611 @default.
- W3022805972 hasPublicationYear "2008" @default.
- W3022805972 type Work @default.
- W3022805972 sameAs 3022805972 @default.
- W3022805972 citedByCount "0" @default.
- W3022805972 crossrefType "journal-article" @default.
- W3022805972 hasAuthorship W3022805972A5004116275 @default.
- W3022805972 hasAuthorship W3022805972A5015609876 @default.
- W3022805972 hasAuthorship W3022805972A5037519871 @default.
- W3022805972 hasAuthorship W3022805972A5050940474 @default.
- W3022805972 hasAuthorship W3022805972A5071781931 @default.
- W3022805972 hasAuthorship W3022805972A5081444133 @default.
- W3022805972 hasConcept C147483822 @default.
- W3022805972 hasConcept C167672396 @default.
- W3022805972 hasConcept C169760540 @default.
- W3022805972 hasConcept C203014093 @default.
- W3022805972 hasConcept C2776090121 @default.
- W3022805972 hasConcept C2778531937 @default.
- W3022805972 hasConcept C2778609137 @default.
- W3022805972 hasConcept C2780640218 @default.
- W3022805972 hasConcept C2780876595 @default.
- W3022805972 hasConcept C529278444 @default.
- W3022805972 hasConcept C86803240 @default.
- W3022805972 hasConcept C8891405 @default.
- W3022805972 hasConcept C95444343 @default.
- W3022805972 hasConceptScore W3022805972C147483822 @default.
- W3022805972 hasConceptScore W3022805972C167672396 @default.
- W3022805972 hasConceptScore W3022805972C169760540 @default.
- W3022805972 hasConceptScore W3022805972C203014093 @default.
- W3022805972 hasConceptScore W3022805972C2776090121 @default.
- W3022805972 hasConceptScore W3022805972C2778531937 @default.
- W3022805972 hasConceptScore W3022805972C2778609137 @default.
- W3022805972 hasConceptScore W3022805972C2780640218 @default.
- W3022805972 hasConceptScore W3022805972C2780876595 @default.
- W3022805972 hasConceptScore W3022805972C529278444 @default.
- W3022805972 hasConceptScore W3022805972C86803240 @default.
- W3022805972 hasConceptScore W3022805972C8891405 @default.
- W3022805972 hasConceptScore W3022805972C95444343 @default.
- W3022805972 hasLocation W30228059721 @default.
- W3022805972 hasOpenAccess W3022805972 @default.
- W3022805972 hasPrimaryLocation W30228059721 @default.
- W3022805972 hasRelatedWork W135905454 @default.
- W3022805972 hasRelatedWork W1967953573 @default.
- W3022805972 hasRelatedWork W1969416680 @default.
- W3022805972 hasRelatedWork W1996336884 @default.
- W3022805972 hasRelatedWork W2031269239 @default.
- W3022805972 hasRelatedWork W2048950972 @default.
- W3022805972 hasRelatedWork W2049035278 @default.
- W3022805972 hasRelatedWork W2078326745 @default.
- W3022805972 hasRelatedWork W2086798154 @default.
- W3022805972 hasRelatedWork W2103059117 @default.
- W3022805972 hasRelatedWork W2110690646 @default.
- W3022805972 hasRelatedWork W2153011646 @default.
- W3022805972 hasRelatedWork W2326246211 @default.
- W3022805972 hasRelatedWork W2337982855 @default.
- W3022805972 hasRelatedWork W2376750075 @default.
- W3022805972 hasRelatedWork W2744630653 @default.
- W3022805972 hasRelatedWork W2967948249 @default.
- W3022805972 hasRelatedWork W2990574486 @default.
- W3022805972 hasRelatedWork W3165920332 @default.
- W3022805972 hasRelatedWork W637454034 @default.
- W3022805972 isParatext "false" @default.
- W3022805972 isRetracted "false" @default.
- W3022805972 magId "3022805972" @default.
- W3022805972 workType "article" @default.