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• W3022814147 abstract "Phase locking of auditory-nerve-fiber (ANF) responses to the temporal fine structure of acoustic stimuli, a hallmark of the auditory system9s temporal precision, is important for many aspects of hearing. Previous work has shown that phase-locked period histograms are often well described by exponential transfer functions relating instantaneous stimulus pressure to instantaneous spike rate, with no observed clipping of the histograms. The operating points and slopes of these functions change with stimulus level. The mechanism underlying this apparent gain control is unclear but is distinct from mechanical compression, is independent of refractoriness and spike-rate adaptation, and is apparently instantaneous. Here we show that these findings can be accounted for by a model consisting of a static Boltzmann transducer function yielding a clipped output, followed by a lowpass filter and a static exponential transfer function. Using responses to tones of ANFs from cats of both sexes, we show that, for a given ANF, the period histograms obtained at all stimulus levels for a given stimulus frequency can be described using one set of level-independent model parameters. The model also accounts for changes in the maximum and minimum instantaneous spike rates with changes in stimulus level. Notably, the estimated cutoff frequency is lower for low- than for high-spontaneous-rate ANFs, implying a synapse-specific contribution to lowpass filtering. These findings advance our understanding of ANF phase locking by highlighting the role of peripheral filtering mechanisms in shaping responses of individual ANFs. <b>SIGNIFICANCE STATEMENT</b> Phase locking of auditory-nerve-fiber responses to the temporal fine structure of acoustic stimuli is important for many aspects of hearing. Period histograms typically retain an approximately sinusoidal shape across stimulus levels, with the peripheral auditory system operating as though its overall transfer function is an exponential function whose slope decreases with increasing stimulus level. This apparent gain control can be accounted for by a static saturating transducer function followed by a lowpass filter. In addition to attenuating the AC component, the filter approximately recovers the sinusoidal waveform of the stimulus. The estimated cutoff frequency varies with spontaneous rate, revealing a synaptic contribution to lowpass filtering. These findings highlight the significant impact of peripheral filtering mechanisms on phase locking." @default.
• W3022814147 created "2020-05-13" @default.
• W3022814147 creator A5006229629 @default.
• W3022814147 creator A5059773941 @default.
• W3022814147 date "2020-05-06" @default.
• W3022814147 modified "2023-09-27" @default.
• W3022814147 title "Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells" @default.
• W3022814147 cites W1522557328 @default.
• W3022814147 cites W1575313762 @default.
• W3022814147 cites W1694767778 @default.
• W3022814147 cites W1963709786 @default.
• W3022814147 cites W1964532154 @default.
• W3022814147 cites W1965034457 @default.
• W3022814147 cites W1968878280 @default.
• W3022814147 cites W1972168487 @default.
• W3022814147 cites W1972993095 @default.
• W3022814147 cites W1973996018 @default.
• W3022814147 cites W1980989105 @default.
• W3022814147 cites W1986196987 @default.
• W3022814147 cites W1989894205 @default.
• W3022814147 cites W1992222345 @default.
• W3022814147 cites W1996743323 @default.
• W3022814147 cites W1997345739 @default.
• W3022814147 cites W1999790282 @default.
• W3022814147 cites W1999962454 @default.
• W3022814147 cites W2000334073 @default.
• W3022814147 cites W2006491358 @default.
• W3022814147 cites W2006623752 @default.
• W3022814147 cites W2009073013 @default.
• W3022814147 cites W2011297027 @default.
• W3022814147 cites W2012431772 @default.
• W3022814147 cites W2012692872 @default.
• W3022814147 cites W2020885203 @default.
• W3022814147 cites W2027505036 @default.
• W3022814147 cites W2037735994 @default.
• W3022814147 cites W2039511769 @default.
• W3022814147 cites W2039716172 @default.
• W3022814147 cites W2040673688 @default.
• W3022814147 cites W2044664542 @default.
• W3022814147 cites W2045206593 @default.
• W3022814147 cites W2048058235 @default.
• W3022814147 cites W2060401989 @default.
• W3022814147 cites W2061227857 @default.
• W3022814147 cites W2066895679 @default.
• W3022814147 cites W2068076458 @default.
• W3022814147 cites W2069121426 @default.
• W3022814147 cites W2079165672 @default.
• W3022814147 cites W2079403368 @default.
• W3022814147 cites W2081279025 @default.
• W3022814147 cites W2081439231 @default.
• W3022814147 cites W2083147301 @default.
• W3022814147 cites W2085150801 @default.
• W3022814147 cites W2088565339 @default.
• W3022814147 cites W2088963104 @default.
• W3022814147 cites W2089580701 @default.
• W3022814147 cites W2090424935 @default.
• W3022814147 cites W2100812312 @default.
• W3022814147 cites W2105961139 @default.
• W3022814147 cites W2109447493 @default.
• W3022814147 cites W2118096540 @default.
• W3022814147 cites W2123007261 @default.
• W3022814147 cites W2134573308 @default.
• W3022814147 cites W2137453923 @default.
• W3022814147 cites W2140428571 @default.
• W3022814147 cites W2171061694 @default.
• W3022814147 cites W2171965202 @default.
• W3022814147 cites W2186445644 @default.
• W3022814147 cites W2287856065 @default.
• W3022814147 cites W2482089764 @default.
• W3022814147 cites W2502203105 @default.
• W3022814147 cites W2530900944 @default.
• W3022814147 cites W2588428063 @default.
• W3022814147 cites W2755895368 @default.
• W3022814147 cites W2781404744 @default.
• W3022814147 cites W2795452021 @default.
• W3022814147 cites W2803795685 @default.
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• W3022814147 cites W2888158907 @default.
• W3022814147 cites W2921598257 @default.
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• W3022814147 doi "https://doi.org/10.1523/jneurosci.2269-19.2020" @default.
• W3022814147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7294794" @default.
• W3022814147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32376778" @default.
• W3022814147 hasPublicationYear "2020" @default.
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