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- W3022819863 abstract "Abstract Impaired wound healing is a frequent complication in patients with diabetes that often results in lower-limb amputation. Normal wound healing proceeds through a series of phases that initially allow for disinfection of the wound site, then progress to rebuilding and remodeling of the tissue. In the context of diabetes, the transition to the reparative phases is impeded and the process becomes fixed in a proinflammatory state promoting destruction of the tissue. Evidence shows that prolonged hyperglycemia leads to altered transcriptional programming of inflammatory cells causing them to remain in a pro/hyperinflammatory state and that this effect can remain after blood glucose is controlled. In this chapter, we discuss alterations in the immune cells during diabetic wound healing and describe some of the mechanisms involved in these changes." @default.
- W3022819863 created "2020-05-13" @default.
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- W3022819863 date "2020-01-01" @default.
- W3022819863 modified "2023-10-17" @default.
- W3022819863 title "Dysregulated inflammation in diabetic wounds" @default.
- W3022819863 doi "https://doi.org/10.1016/b978-0-12-816413-6.00005-8" @default.
- W3022819863 hasPublicationYear "2020" @default.
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