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- W3022821483 abstract "Despite Simona Cicero and colleagues' findings,1Cicero S Curcio P Papageorghiou A Sonek J Nicolaides K Absence of nasal bone in fetuses with trisomy 21 at 11–14 weeks of gestation: an observational study.Lancet. 2001; 358: 1665-1667Summary Full Text Full Text PDF PubMed Scopus (447) Google Scholar we note that, on review of our last five cases of Down's syndrome, in which routine ultrasonography was done for nuchal translucency, nasal bones were seen in all five (figure). On the basis of the results of Cicero and colleagues, the nasal bone should have been absent in four of the five cases. We think that Howard Cuckle's encouragement to introduce this marker in screening2Cuckle H Time for total shift to first trimester screening for Down's syndrome.Lancet. 2001; 358: 1658-1659Summary Full Text Full Text PDF PubMed Scopus (59) Google Scholar is premature. Further research is necessary to assess the performance of this screening marker before it can be used in medical practice. Absence of nasal bone and detection of trisomy 21Author's reply Full-Text PDF" @default.
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- W3022821483 date "2002-04-01" @default.
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- W3022821483 title "Absence of nasal bone and detection of trisomy 21" @default.
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- W3022821483 doi "https://doi.org/10.1016/s0140-6736(02)08289-2" @default.
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