FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022831187> ?p ?o ?g. }

• W3022831187 endingPage "119731" @default.
• W3022831187 startingPage "119731" @default.
• W3022831187 abstract "A series of heterobimetallic [Fe,Ru] and homobimetallic [Fe,Fe] complexes, featuring µ -diphosphine bridges between the two metal centres, are reported along with their in vitro cytotoxicity activity on the A2780cisR cell-line. The known starting material [CpFe(CO)2(CH3)] (Cp = η5-C5H5) (1) was reacted with dppe (1,2-bis(diphenylphosphino)ethane) forming the known mononuclear κ1-dppe complex: [CpFe(CO)(COCH3)(κ1-dppe)] (2) and the known dinuclear complex: and [[CpFe(CO)(COCH3)]2(µ-dppe)] (3). Dimer cleavage reactions between complex 2 and two ruthenium arene complexes [(η6-p-cymene)RuCl2]2 and [(η6-benzene)RuCl2]2 formed two new heterobimetallic complexes: [CpFe(CO)(COCH3)(µ-dppe)Ru(η6-cymene)Cl2] (4) and [CpFe(CO)(COCH3)(µ-dppe)Ru(η6-C6H6)Cl2] (5). A homobimetallic system, [[CpFe(CO)(I)]2(µ-dppb)] (6) was obtained by the facile reaction between of [CpFe(CO)2I] and 1,4-bis(diphenylphosphino)butane (dppb). Complex 6 was methylated using MeLi to generate the more lipophilic complex [[CpFe(CO)(CH3)]2(µ-dppb)] (7). All of the complexes were fully characterized by spectroscopy (1H, 13C {1H}, 31P {1H} NMR; FTIR, UV–Vis), and high resolution mass spectrometry (HRMS). Density functional theory calculations (DFT) (Level of theory B3LYP, basis set for H, C, P, O, Cl is 6-31+G(d,p) and for Ru, Fe, I is DGDZVP) on complexes 5 and 6 are also reported. An excellent agreement between the DFT calculated infra-red (IR) spectra of the optimised geometries of 5 and 6 was found with the experimentally determined spectra. In vitro cytotoxicity studies of all complexes was carried out on A2780cisR (cisplatin resistant ovarian cancer cell-line) and compared to cisplatin as a positive control and RAPTA-C as a negative control. Although limited to only one cell-line, the results show that the heterobimetallic complexes 4 and 5 are the most cytotoxic (IC50 = 4.9 ± 0.4 µM and 6.5 ± 0.1 µM respectively), whilst the dinculear [Fe,Fe] complexes exhibit no, or very low cytotoxicity." @default.
• W3022831187 created "2020-05-13" @default.
• W3022831187 creator A5010031471 @default.
• W3022831187 creator A5013357331 @default.
• W3022831187 creator A5044433603 @default.
• W3022831187 creator A5053092970 @default.
• W3022831187 creator A5066842157 @default.
• W3022831187 date "2020-09-01" @default.
• W3022831187 modified "2023-10-02" @default.
• W3022831187 title "Facile synthesis of heterobimetallic [FeII(µ-diphosphine)RuII] and homobimetallic [FeII(µ-diphosphine)FeII] complexes and their in vitro cytotoxic activity on cisplatin-resistant cancer cells" @default.
• W3022831187 cites W1178498256 @default.
• W3022831187 cites W127176811 @default.
• W3022831187 cites W1563080572 @default.
• W3022831187 cites W165233922 @default.
• W3022831187 cites W1829575213 @default.
• W3022831187 cites W1832722687 @default.
• W3022831187 cites W1907795058 @default.
• W3022831187 cites W1951893327 @default.
• W3022831187 cites W1964433007 @default.
• W3022831187 cites W1965186484 @default.
• W3022831187 cites W1965587418 @default.
• W3022831187 cites W1966980421 @default.
• W3022831187 cites W1974590772 @default.
• W3022831187 cites W1978595756 @default.
• W3022831187 cites W1986316733 @default.
• W3022831187 cites W1986939164 @default.
• W3022831187 cites W1987604182 @default.
• W3022831187 cites W2008402290 @default.
• W3022831187 cites W2017346763 @default.
• W3022831187 cites W2021609364 @default.
• W3022831187 cites W2028738450 @default.
• W3022831187 cites W2029852148 @default.
• W3022831187 cites W2032457496 @default.
• W3022831187 cites W2035690443 @default.
• W3022831187 cites W2044265118 @default.
• W3022831187 cites W2048168597 @default.
• W3022831187 cites W2049811778 @default.
• W3022831187 cites W2050569993 @default.
• W3022831187 cites W2050601207 @default.
• W3022831187 cites W2062107099 @default.
• W3022831187 cites W2066825427 @default.
• W3022831187 cites W2075443207 @default.
• W3022831187 cites W2082602947 @default.
• W3022831187 cites W2082810110 @default.
• W3022831187 cites W2084069886 @default.
• W3022831187 cites W2089003405 @default.
• W3022831187 cites W2095569509 @default.
• W3022831187 cites W2099473254 @default.
• W3022831187 cites W2100388226 @default.
• W3022831187 cites W2101539565 @default.
• W3022831187 cites W2114918609 @default.
• W3022831187 cites W2120831117 @default.
• W3022831187 cites W2139187462 @default.
• W3022831187 cites W2140895245 @default.
• W3022831187 cites W2145706133 @default.
• W3022831187 cites W2147328441 @default.
• W3022831187 cites W2149352862 @default.
• W3022831187 cites W2153732959 @default.
• W3022831187 cites W2256843984 @default.
• W3022831187 cites W2514483667 @default.
• W3022831187 cites W2561936059 @default.
• W3022831187 cites W2591580144 @default.
• W3022831187 cites W2735343075 @default.
• W3022831187 cites W2738757219 @default.
• W3022831187 cites W2773271959 @default.
• W3022831187 cites W2782044648 @default.
• W3022831187 cites W2806554548 @default.
• W3022831187 cites W2890137922 @default.
• W3022831187 cites W2896377507 @default.
• W3022831187 cites W2898304055 @default.
• W3022831187 cites W2908704974 @default.
• W3022831187 cites W2910892797 @default.
• W3022831187 cites W2914653692 @default.
• W3022831187 cites W2914855163 @default.
• W3022831187 cites W2938455215 @default.
• W3022831187 cites W2942987360 @default.
• W3022831187 cites W2967107515 @default.
• W3022831187 cites W2968098355 @default.
• W3022831187 cites W2970639571 @default.
• W3022831187 cites W2971808344 @default.
• W3022831187 cites W2973014957 @default.
• W3022831187 doi "https://doi.org/10.1016/j.ica.2020.119731" @default.
• W3022831187 hasPublicationYear "2020" @default.
• W3022831187 type Work @default.
• W3022831187 sameAs 3022831187 @default.
• W3022831187 citedByCount "7" @default.
• W3022831187 countsByYear W30228311872021 @default.
• W3022831187 countsByYear W30228311872022 @default.
• W3022831187 countsByYear W30228311872023 @default.
• W3022831187 crossrefType "journal-article" @default.
• W3022831187 hasAuthorship W3022831187A5010031471 @default.
• W3022831187 hasAuthorship W3022831187A5013357331 @default.
• W3022831187 hasAuthorship W3022831187A5044433603 @default.
• W3022831187 hasAuthorship W3022831187A5053092970 @default.
• W3022831187 hasAuthorship W3022831187A5066842157 @default.
• W3022831187 hasBestOaLocation W30228311871 @default.
• W3022831187 hasConcept C155647269 @default.
• W3022831187 hasConcept C161790260 @default.

• next