FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022831706> ?p ?o ?g. }

• W3022831706 endingPage "3157" @default.
• W3022831706 startingPage "3157" @default.
• W3022831706 abstract "Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies. Although they were designed to target aberrant tyrosine kinases, they are also intimately linked with the mechanisms of multidrug resistance (MDR) in cancer cells. MDR-related solute carrier (SLC) and ATB-binding cassette (ABC) transporters are responsible for TKI uptake and efflux, respectively. However, the role of TKIs appears to be dual because they can act as substrates and/or inhibitors of these transporters. In addition, several TKIs have been identified to be sequestered into lysosomes either due to their physiochemical properties or via ABC transporters expressed on the lysosomal membrane. Since the development of MDR represents a great concern in anticancer treatment, it is important to elucidate the interactions of TKIs with MDR-related transporters as well as to improve the properties that would prevent TKIs from diffusing into lysosomes. These findings not only help to avoid MDR, but also help to define the possible impact of combining TKIs with other anticancer drugs, leading to more efficient therapy and fewer adverse effects in patients." @default.
• W3022831706 created "2020-05-13" @default.
• W3022831706 creator A5014694628 @default.
• W3022831706 creator A5065448655 @default.
• W3022831706 creator A5066573952 @default.
• W3022831706 creator A5075042319 @default.
• W3022831706 creator A5090156198 @default.
• W3022831706 date "2020-04-30" @default.
• W3022831706 modified "2023-10-05" @default.
• W3022831706 title "Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration" @default.
• W3022831706 cites W1041672667 @default.
• W3022831706 cites W10640494 @default.
• W3022831706 cites W1506738181 @default.
• W3022831706 cites W1545790530 @default.
• W3022831706 cites W1546346721 @default.
• W3022831706 cites W1936230651 @default.
• W3022831706 cites W1959140065 @default.
• W3022831706 cites W1964845997 @default.
• W3022831706 cites W1967920366 @default.
• W3022831706 cites W1970238406 @default.
• W3022831706 cites W1970373339 @default.
• W3022831706 cites W1971495943 @default.
• W3022831706 cites W1975051553 @default.
• W3022831706 cites W1976463957 @default.
• W3022831706 cites W1977202771 @default.
• W3022831706 cites W1982513324 @default.
• W3022831706 cites W1983600229 @default.
• W3022831706 cites W1992069798 @default.
• W3022831706 cites W2003640047 @default.
• W3022831706 cites W2013658500 @default.
• W3022831706 cites W2014790162 @default.
• W3022831706 cites W2015485124 @default.
• W3022831706 cites W2017728128 @default.
• W3022831706 cites W2024065277 @default.
• W3022831706 cites W2025669680 @default.
• W3022831706 cites W2029303104 @default.
• W3022831706 cites W2029363767 @default.
• W3022831706 cites W2031240327 @default.
• W3022831706 cites W2033151149 @default.
• W3022831706 cites W2033779255 @default.
• W3022831706 cites W2038695289 @default.
• W3022831706 cites W2045992174 @default.
• W3022831706 cites W2047076340 @default.
• W3022831706 cites W2047264879 @default.
• W3022831706 cites W2049055032 @default.
• W3022831706 cites W2050939666 @default.
• W3022831706 cites W2053411009 @default.
• W3022831706 cites W2053949262 @default.
• W3022831706 cites W2059932769 @default.
• W3022831706 cites W2060415903 @default.
• W3022831706 cites W2061860992 @default.
• W3022831706 cites W2069277433 @default.
• W3022831706 cites W2069907205 @default.
• W3022831706 cites W2070791205 @default.
• W3022831706 cites W2075093463 @default.
• W3022831706 cites W2077422669 @default.
• W3022831706 cites W2078543981 @default.
• W3022831706 cites W2081878699 @default.
• W3022831706 cites W2082043766 @default.
• W3022831706 cites W2083698338 @default.
• W3022831706 cites W2086327042 @default.
• W3022831706 cites W2087077468 @default.
• W3022831706 cites W2087402693 @default.
• W3022831706 cites W2088750799 @default.
• W3022831706 cites W2094793616 @default.
• W3022831706 cites W2098064809 @default.
• W3022831706 cites W2098516378 @default.
• W3022831706 cites W2101884133 @default.
• W3022831706 cites W2102590541 @default.
• W3022831706 cites W2105968397 @default.
• W3022831706 cites W2106533048 @default.
• W3022831706 cites W2107841381 @default.
• W3022831706 cites W2108486409 @default.
• W3022831706 cites W2108756633 @default.
• W3022831706 cites W2109340655 @default.
• W3022831706 cites W2109399507 @default.
• W3022831706 cites W2111072132 @default.
• W3022831706 cites W2114528819 @default.
• W3022831706 cites W2117365333 @default.
• W3022831706 cites W2118084423 @default.
• W3022831706 cites W2122210921 @default.
• W3022831706 cites W2126968146 @default.
• W3022831706 cites W2129060478 @default.
• W3022831706 cites W2129402323 @default.
• W3022831706 cites W2130598119 @default.
• W3022831706 cites W2131582481 @default.
• W3022831706 cites W2132046158 @default.
• W3022831706 cites W2139909466 @default.
• W3022831706 cites W2144438174 @default.
• W3022831706 cites W2150231804 @default.
• W3022831706 cites W2151467658 @default.
• W3022831706 cites W2152194109 @default.
• W3022831706 cites W2155146034 @default.
• W3022831706 cites W2155229204 @default.
• W3022831706 cites W2155383511 @default.
• W3022831706 cites W2157017490 @default.
• W3022831706 cites W2159738503 @default.
• W3022831706 cites W2161000665 @default.

• next