FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022843341> ?p ?o ?g. }

• W3022843341 endingPage "949" @default.
• W3022843341 startingPage "939" @default.
• W3022843341 abstract "Autosomal dominant leukodystrophy (ADLD) is a fatal, progressive adult-onset disease characterized by widespread central nervous system (CNS) demyelination and significant morbidity. The late age of onset together with the relatively slow disease progression provides a large therapeutic window for the disorder. However, no treatment exists for ADLD, representing an urgent and unmet clinical need. We have previously shown that ADLD is caused by duplications of the lamin B1 gene causing increased expression of the lamin B1 protein, a major constituent of the nuclear lamina, and demonstrated that transgenic mice with oligodendrocyte-specific overexpression of lamin B1 exhibit temporal and histopathological features reminiscent of the human disease. As increased levels of lamin B1 are the causative event triggering ADLD, approaches aimed at reducing lamin B1 levels and associated functional consequences represent a promising strategy for discovery of small-molecule ADLD therapeutics. To this end, we have created an inducible cell culture model of lamin B1 overexpression and developed high-content analysis in connection with multivariate analysis to define, analyze, and quantify lamin B1 expression and its associated abnormal nuclear phenotype in mouse embryonic fibroblasts (MEFs). The assay has been optimized to meet high-throughput screening (HTS) criteria in multiday variability studies. To control for batch-to-batch variation in the primary MEFs, we have implemented a screening strategy that employs sentinel cells to avoid costly losses during HTS. We posit the assay will identify bona fide suppressors of lamin B1 pathophysiology as candidates for development into potential therapies for ADLD." @default.
• W3022843341 created "2020-05-13" @default.
• W3022843341 creator A5011676332 @default.
• W3022843341 creator A5024395786 @default.
• W3022843341 creator A5029471010 @default.
• W3022843341 creator A5056586582 @default.
• W3022843341 creator A5069631333 @default.
• W3022843341 creator A5070873672 @default.
• W3022843341 creator A5085025467 @default.
• W3022843341 creator A5087527556 @default.
• W3022843341 creator A5090725127 @default.
• W3022843341 date "2020-09-01" @default.
• W3022843341 modified "2023-10-16" @default.
• W3022843341 title "Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy" @default.
• W3022843341 cites W1540188781 @default.
• W3022843341 cites W1586552429 @default.
• W3022843341 cites W1953902679 @default.
• W3022843341 cites W1991001144 @default.
• W3022843341 cites W2010335932 @default.
• W3022843341 cites W2012181460 @default.
• W3022843341 cites W2013127588 @default.
• W3022843341 cites W2018275041 @default.
• W3022843341 cites W2029610799 @default.
• W3022843341 cites W2036778813 @default.
• W3022843341 cites W2040002798 @default.
• W3022843341 cites W2044679188 @default.
• W3022843341 cites W2070299769 @default.
• W3022843341 cites W2086020778 @default.
• W3022843341 cites W2092062541 @default.
• W3022843341 cites W2110488105 @default.
• W3022843341 cites W2134685898 @default.
• W3022843341 cites W2136835005 @default.
• W3022843341 cites W2159154780 @default.
• W3022843341 cites W2160703969 @default.
• W3022843341 cites W2164979641 @default.
• W3022843341 cites W2743630123 @default.
• W3022843341 cites W2911484115 @default.
• W3022843341 cites W2912456573 @default.
• W3022843341 cites W2915502420 @default.
• W3022843341 doi "https://doi.org/10.1177/2472555220915821" @default.
• W3022843341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7755098" @default.
• W3022843341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32349647" @default.
• W3022843341 hasPublicationYear "2020" @default.
• W3022843341 type Work @default.
• W3022843341 sameAs 3022843341 @default.
• W3022843341 citedByCount "3" @default.
• W3022843341 countsByYear W30228433412021 @default.
• W3022843341 countsByYear W30228433412023 @default.
• W3022843341 crossrefType "journal-article" @default.
• W3022843341 hasAuthorship W3022843341A5011676332 @default.
• W3022843341 hasAuthorship W3022843341A5024395786 @default.
• W3022843341 hasAuthorship W3022843341A5029471010 @default.
• W3022843341 hasAuthorship W3022843341A5056586582 @default.
• W3022843341 hasAuthorship W3022843341A5069631333 @default.
• W3022843341 hasAuthorship W3022843341A5070873672 @default.
• W3022843341 hasAuthorship W3022843341A5085025467 @default.
• W3022843341 hasAuthorship W3022843341A5087527556 @default.
• W3022843341 hasAuthorship W3022843341A5090725127 @default.
• W3022843341 hasBestOaLocation W30228433411 @default.
• W3022843341 hasConcept C102230213 @default.
• W3022843341 hasConcept C104317684 @default.
• W3022843341 hasConcept C127716648 @default.
• W3022843341 hasConcept C142724271 @default.
• W3022843341 hasConcept C179093185 @default.
• W3022843341 hasConcept C2776100374 @default.
• W3022843341 hasConcept C2779134260 @default.
• W3022843341 hasConcept C29512474 @default.
• W3022843341 hasConcept C502942594 @default.
• W3022843341 hasConcept C54355233 @default.
• W3022843341 hasConcept C71924100 @default.
• W3022843341 hasConcept C86339819 @default.
• W3022843341 hasConcept C86803240 @default.
• W3022843341 hasConcept C94912109 @default.
• W3022843341 hasConcept C95444343 @default.
• W3022843341 hasConceptScore W3022843341C102230213 @default.
• W3022843341 hasConceptScore W3022843341C104317684 @default.
• W3022843341 hasConceptScore W3022843341C127716648 @default.
• W3022843341 hasConceptScore W3022843341C142724271 @default.
• W3022843341 hasConceptScore W3022843341C179093185 @default.
• W3022843341 hasConceptScore W3022843341C2776100374 @default.
• W3022843341 hasConceptScore W3022843341C2779134260 @default.
• W3022843341 hasConceptScore W3022843341C29512474 @default.
• W3022843341 hasConceptScore W3022843341C502942594 @default.
• W3022843341 hasConceptScore W3022843341C54355233 @default.
• W3022843341 hasConceptScore W3022843341C71924100 @default.
• W3022843341 hasConceptScore W3022843341C86339819 @default.
• W3022843341 hasConceptScore W3022843341C86803240 @default.
• W3022843341 hasConceptScore W3022843341C94912109 @default.
• W3022843341 hasConceptScore W3022843341C95444343 @default.
• W3022843341 hasFunder F4320337359 @default.
• W3022843341 hasIssue "8" @default.
• W3022843341 hasLocation W30228433411 @default.
• W3022843341 hasLocation W30228433412 @default.
• W3022843341 hasLocation W30228433413 @default.
• W3022843341 hasOpenAccess W3022843341 @default.
• W3022843341 hasPrimaryLocation W30228433411 @default.
• W3022843341 hasRelatedWork W197228255 @default.
• W3022843341 hasRelatedWork W2035870858 @default.

• next