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- W3022853859 abstract "Despite ongoing efforts, a highly effective vaccine against Plasmodium falciparum remains elusive. Vaccines targeting the pre-erythrocytic stages of the P. falciparum life cycle are the most advanced to date, affording moderate levels of efficacy in field trials. However, the discovery that the members of the merozoite PfRH5-PfCyRPA-PfRipr (RCR) complex are capable of inducing strain-transcendent neutralizing antibodies has renewed enthusiasm for the possibility of preventing disease by targeting the parasite during the blood stage of infection. With Phase I/II clinical trials now underway using first-generation vaccines against PfRH5, and more on the horizon for PfCyRPA and PfRipr, this review explores the rationale and future potential of the RCR complex as a P. falciparum vaccine target." @default.
- W3022853859 created "2020-05-13" @default.
- W3022853859 creator A5002418313 @default.
- W3022853859 creator A5005386266 @default.
- W3022853859 creator A5046793340 @default.
- W3022853859 date "2020-06-01" @default.
- W3022853859 modified "2023-10-17" @default.
- W3022853859 title "The RH5-CyRPA-Ripr Complex as a Malaria Vaccine Target" @default.
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- W3022853859 doi "https://doi.org/10.1016/j.pt.2020.04.003" @default.
- W3022853859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7246332" @default.
- W3022853859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32359873" @default.
- W3022853859 hasPublicationYear "2020" @default.
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