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- W3022857746 abstract "Allylnitrile is known to induce head twitching in rats and mice. Carbon tetrachloride (CCl 4 ) impairs the hepatic mixed function oxidase system and lowers acute toxicity of nitriles. In the present study we examined the effect of CCl 4 on the allylnitrile-induced head twitching to elucidate the mechanism of the abnormal behavior. In rats, CCl 4 pretreatment inhibited the head twitching induced by allylnitrile (1.49 mmole/kg, po), the maximal and dose-dependent inhibition occurring when CCl 4 was given just prior to the nitrile administration, while CCl 4 post-treatment had no effect on the head twitching. A dose-dependent inhibition of cyanide formation arising from allylnitrile in the liver and a dose-dependent attenuation of acute toxicity of allylnitrile were observed when CCl 4 was given just prior to the nitrile administration in rats and mice. Intracerebroventricular injection of allylnitrile (2.0 to 18 μmole/brain) induced no head twitching in rats. The results suggest that active metabolites of allylnitrile are responsible for the head twitching, and that CCl 4 prevents the metabolic process in the liver by forming conjugates with allylnitrile, resulting in the inhibition Of the head twitching. © 1993 Academic Press, Inc." @default.
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- W3022857746 date "1994-01-01" @default.
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- W3022857746 title "Effect of Carbon Tetrachloride on Allylnitrile-Induced Head Twitching" @default.
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- W3022857746 doi "https://doi.org/10.1016/b978-0-12-059785-7.50090-9" @default.
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