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- W3022872787 endingPage "117765" @default.
- W3022872787 startingPage "117765" @default.
- W3022872787 abstract "The ongoing wreaking global outbreak of the novel human beta coronavirus (CoV) pathogen was presumed to be from a seafood wholesale market in Wuhan, China, belongs to the Coronaviridae family in the Nidovirales order. The virus is highly contagious with potential human-human transmission which was named as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread across six continents and emerged as a global pandemic in short span with alarming levels of spread and severity. This virus associated symptoms and infectious respiratory illness is designated as coronavirus disease 19 (COVID-19). The SARS-CoV-2 possesses enveloped club-like spike protein projections with positive-sense large RNA genome and has a unique replication strategy. This virus was believed to have zoonotic origin with genetical identity to bat and pangolin CoV. In the current review, we introduce a general overview about the human CoVs and the associated diseases, the origin, structure, replication and key clinical events that occur in the COVID-19 pathogenicity. Furthermore, we focused on possible therapeutic options such as repurposing drugs including antimalarials, antivirals, antiparasitic drugs, and anti-HIV drugs, as well as monoclonal antibodies, vaccines as potential treatment options. Also we have summarized the latest research progress on the usage of stem cell therapy, human convalescent serum, interferon's, in the treatment of COVID-19." @default.
- W3022872787 created "2020-05-13" @default.
- W3022872787 creator A5001222816 @default.
- W3022872787 creator A5006609573 @default.
- W3022872787 creator A5084614592 @default.
- W3022872787 date "2020-08-01" @default.
- W3022872787 modified "2023-10-10" @default.
- W3022872787 title "The current understanding and potential therapeutic options to combat COVID-19" @default.
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