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- W3022877596 abstract "Neurofibrillary tangles (NFTs) are characteristic neuropathological hallmarks in Alzheimer‘s disease (AD). Their amount is significantly increasing with duration and the severity of the disease. Importantly, NFT counts in vulnerable area of AD brain are significantly associated with cognitive status of the patient. Quantitative neuromorphological study of the NFTs counts in the most vulnerable brain areas of the transgenic rat model in two independent transgenic lines expressing different levels of human truncated tau. This study was carried out using stereological approach on a computer–based stereological system (StereoInvestigator, MicroBrightField) on Nissl stained (neuron counts) and immunohistochemically stained (mAb AT8, NFT counts) sections from selected brain stem areas strongly affected with NFT pathology. Two independent transgenic lines (lines 72 and 318) of presented AD rat model show different expression of human truncated tau, with stronger expression in line 72. The characteristic life span of line 72 is 7–8 months and of line 318 is 10–11 months. Real time PCR revealed that this difference was entirely gene dose dependent.The neurofibrillary degeneration and neurobehavioral changes start significantly earlier in line with higher expression level of truncated tau (line 72). Both lines were stereologically investigated for neuron and NFT counts. The load of NFTs was higher in transgenic line 72 compared to tg. line 318. However, the calculated NFT/neuron ratio (NNR), demonstrating the proportion of affected neurons to whole neuronal population, remains nearly equal (NNR = 0,12) in both transgenic lines. Furthermore tg. line 72 was investigated for possible dependence of NFT load on the gender. The NFT load was different between genders, however again the NFT/neuron ratio was similar. This study showed that onset of neurofibrillary pathology, neurobehavioral changes and life span in AD transgenic rat model studied, were strongly dependent on the expression levels of human truncated tau protein, however not dependent on gender." @default.
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- W3022877596 date "2006-07-01" @default.
- W3022877596 modified "2023-09-27" @default.
- W3022877596 title "P3-323: The onset of neurofibrillary pathology, neurobehavioral changes and life span in transgenic AD rat model is gene-dose dependent and sex-independent" @default.
- W3022877596 doi "https://doi.org/10.1016/j.jalz.2006.05.1593" @default.
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