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• W3022896806 abstract "This chapter highlights eosinophil structure and function and discusses the increasing evidence that eosinophils contribute to the pathogenesis of asthma. Eosinophil is a polymorphonuclear leukocyte produced in the bone marrow from totipotent stem cells. The presence of increased eosinophils in the blood, sputum, bronchoalveolar lavage (BAL) fluid, and bronchial wall of asthma patients is usually correlated with airway obstruction and bronchial hyperresponsiveness. Eosinophilic inflammation of the airways is more common in patients with asthma than in patients with chronic obstructive pulmonary disease (COPD). Eosinophil effector functions—particularly the release of toxic granule proteins and leukotrienes—are fundamental to the pathogenesis of asthma. Peripheral blood and sputum eosinophilia is significantly associated with both allergic and nonallergic asthma. Recent studies have focused on the complex cellular and molecular mechanisms that regulate the recruitment of eosinophils from the blood to the site of inflammation in the airways, and this understanding can lead to the development of several therapeutic agents that have the potential to improve asthma or a part of it by their effects on eosinophils." @default.
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• W3022896806 date "2002-01-01" @default.
• W3022896806 modified "2023-09-25" @default.
• W3022896806 title "Eosinophils" @default.
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• W3022896806 doi "https://doi.org/10.1016/b978-012079028-9/50086-7" @default.
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