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- W3022902014 abstract "Helicobacter pylori is an important pathogen, which colonizes the mucus layer and epithelial mucus of the stomach in approximately 50% of humans worldwide. Once colonized by H. pylori, the human host can remain infected for life, unless intensive antimicrobial therapy is administered. Helicobacter pylori is the principal cause of chronic active gastritis, stomach and peptic ulceration, and classified as a Class I carcinogen for gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Once attached to the gastric mucosa, H. pylori can damage host tissue by causing vacuolation in the epithelial cells. This vacuolation is caused by the production of a cytotoxin called vacuolating cytotoxin A (VacA), a protein which is endocytosed by epithelial cells where it causes endosome-lysosome fusion. Variations of cytotoxin occur such that more aggressive forms are likely to be associated with peptic ulcer, whereas more benign forms of cytotoxin may be associated with gastritis without ulcers. A biofilm is considered to represent a ‘safe’ haven for opportunistic and strict pathogens and these have been suggested to be potential reservoirs for H. pylori in water. There is a paucity of data concerning the effectiveness of standard drinking water disinfection processes on H. pylori. This chapter discusses H. pylori, including aspects of its basic microbiology, natural history, metabolism and physiology, clinical features, pathogenicity and virulence, survival in the environment, survival in water and epidemiology, evidence for growth in a biofilm, methods of detection, antimicrobial control, and finally, risk assessment." @default.
- W3022902014 created "2020-05-13" @default.
- W3022902014 creator A5026562442 @default.
- W3022902014 creator A5061005935 @default.
- W3022902014 date "2014-01-01" @default.
- W3022902014 modified "2023-10-18" @default.
- W3022902014 title "Helicobacter pylori" @default.
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