FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022927685> ?p ?o ?g. }

• W3022927685 abstract "Abstract BACKGROUND: Several reports have indicated that distinct epigenomic patterns of pituitary tumors (PT), specifically DNA methylation, distinguish these tumor tissues according to their functionality and could be involved in their pathogenesis. Thus far, molecular diagnosis and classification criteria that guide clinical management of these tumors rely on the tissue profiling obtained by invasive surgical approaches (e.g. excision). However, increasing evidence confirmed that central nervous system (CNS) tumors release cell material into the circulation creating an opportunity for molecular profiling of these tumors using a blood-based liquid biopsy. Considering that 1) the pituitary portal system and the invasion of the cavernous system by PT may facilitate the spillage of tumor cell material into the bloodstream and 2) the stability, cell-specificity and reportedly the role of DNA methylation in PT, we hypothesized that liquid biopsy would be feasible to detect and define specific methylation-based signatures in the serum of patients harboring PT. Methods and Findings: We conducted analyses of the methylomes of paired serum circulating cell-free DNA (cfDNA) and tumor tissue from patients harboring PT (EPIC array) to identify serum-derived pituitary tumor-specific methylation-based signatures (sPTMet n=37) in a cohort comprised by 13 patients with pituitary macroadenomas (9 males; median age: 62; 9 Nonfunctioning/4functioning, 6 invasive/7noninvasive), 4 controls (non-tumor) and patients with other CNS tumors or conditions (114 gliomas, 6 meningiomas, 1 brain metastasis, 1 colloid cyst, 6 radiation necrosis). Unsupervised and supervised analysis indicated that the serum methylome from patients harboring PT was distinct from controls and other CNS diseases. Using the sPTMet as input into a machine learning algorithm, we generated a PT score that classified the serum of an independent cohort as PT or non-PT, with high accuracy. We identified serum-derived differentially methylated probes (DMP, n=3288) that distinguished PT according to their function (functioning and nonfunctioning). When overlapped with an independent cohort, these DMP also distinguished PT tissue according to their functional status. Conclusion: Our results showed the feasibility to identify PT-specific methylation signatures by profiling the methylome of serum cfDNA from patients with PT. These signatures distinguished PT from other CNS tumors and according to their subtypes. These results underpin the potential role of methylation profile and liquid biopsy as a noninvasive approach to assess clinically relevant molecular features. Potentially, tumor-specific serum-derived methylation signature may be used as a diagnostic, prognostic and surveillance tool as well to identify actionable molecular markers in patients with PT." @default.
• W3022927685 created "2020-05-13" @default.
• W3022927685 creator A5004697744 @default.
• W3022927685 creator A5013384985 @default.
• W3022927685 creator A5024222984 @default.
• W3022927685 creator A5026869480 @default.
• W3022927685 creator A5027822510 @default.
• W3022927685 creator A5028225585 @default.
• W3022927685 creator A5035576833 @default.
• W3022927685 creator A5042189116 @default.
• W3022927685 creator A5048196706 @default.
• W3022927685 creator A5050883467 @default.
• W3022927685 creator A5052634885 @default.
• W3022927685 creator A5056539671 @default.
• W3022927685 creator A5058287511 @default.
• W3022927685 creator A5059698282 @default.
• W3022927685 creator A5069519658 @default.
• W3022927685 creator A5069699492 @default.
• W3022927685 creator A5070637070 @default.
• W3022927685 creator A5074456638 @default.
• W3022927685 creator A5075209009 @default.
• W3022927685 creator A5078471371 @default.
• W3022927685 creator A5080096952 @default.
• W3022927685 date "2020-04-01" @default.
• W3022927685 modified "2023-09-25" @default.
• W3022927685 title "OR32-03 Serum Cell-Free Methylation-Based Signatures Distinguishes Pituitary Tumors According to Functional Status and from Other Neoplasia: A Liquid Biopsy Approach" @default.
• W3022927685 doi "https://doi.org/10.1210/jendso/bvaa046.542" @default.
• W3022927685 hasPublicationYear "2020" @default.
• W3022927685 type Work @default.
• W3022927685 sameAs 3022927685 @default.
• W3022927685 citedByCount "0" @default.
• W3022927685 crossrefType "journal-article" @default.
• W3022927685 hasAuthorship W3022927685A5004697744 @default.
• W3022927685 hasAuthorship W3022927685A5013384985 @default.
• W3022927685 hasAuthorship W3022927685A5024222984 @default.
• W3022927685 hasAuthorship W3022927685A5026869480 @default.
• W3022927685 hasAuthorship W3022927685A5027822510 @default.
• W3022927685 hasAuthorship W3022927685A5028225585 @default.
• W3022927685 hasAuthorship W3022927685A5035576833 @default.
• W3022927685 hasAuthorship W3022927685A5042189116 @default.
• W3022927685 hasAuthorship W3022927685A5048196706 @default.
• W3022927685 hasAuthorship W3022927685A5050883467 @default.
• W3022927685 hasAuthorship W3022927685A5052634885 @default.
• W3022927685 hasAuthorship W3022927685A5056539671 @default.
• W3022927685 hasAuthorship W3022927685A5058287511 @default.
• W3022927685 hasAuthorship W3022927685A5059698282 @default.
• W3022927685 hasAuthorship W3022927685A5069519658 @default.
• W3022927685 hasAuthorship W3022927685A5069699492 @default.
• W3022927685 hasAuthorship W3022927685A5070637070 @default.
• W3022927685 hasAuthorship W3022927685A5074456638 @default.
• W3022927685 hasAuthorship W3022927685A5075209009 @default.
• W3022927685 hasAuthorship W3022927685A5078471371 @default.
• W3022927685 hasAuthorship W3022927685A5080096952 @default.
• W3022927685 hasBestOaLocation W30229276851 @default.
• W3022927685 hasConcept C104317684 @default.
• W3022927685 hasConcept C121608353 @default.
• W3022927685 hasConcept C126322002 @default.
• W3022927685 hasConcept C142724271 @default.
• W3022927685 hasConcept C150194340 @default.
• W3022927685 hasConcept C190727270 @default.
• W3022927685 hasConcept C2775934546 @default.
• W3022927685 hasConcept C2779130545 @default.
• W3022927685 hasConcept C2779160599 @default.
• W3022927685 hasConcept C2779529041 @default.
• W3022927685 hasConcept C2781449511 @default.
• W3022927685 hasConcept C33288867 @default.
• W3022927685 hasConcept C41091548 @default.
• W3022927685 hasConcept C502942594 @default.
• W3022927685 hasConcept C54355233 @default.
• W3022927685 hasConcept C552990157 @default.
• W3022927685 hasConcept C55493867 @default.
• W3022927685 hasConcept C71924100 @default.
• W3022927685 hasConcept C86803240 @default.
• W3022927685 hasConceptScore W3022927685C104317684 @default.
• W3022927685 hasConceptScore W3022927685C121608353 @default.
• W3022927685 hasConceptScore W3022927685C126322002 @default.
• W3022927685 hasConceptScore W3022927685C142724271 @default.
• W3022927685 hasConceptScore W3022927685C150194340 @default.
• W3022927685 hasConceptScore W3022927685C190727270 @default.
• W3022927685 hasConceptScore W3022927685C2775934546 @default.
• W3022927685 hasConceptScore W3022927685C2779130545 @default.
• W3022927685 hasConceptScore W3022927685C2779160599 @default.
• W3022927685 hasConceptScore W3022927685C2779529041 @default.
• W3022927685 hasConceptScore W3022927685C2781449511 @default.
• W3022927685 hasConceptScore W3022927685C33288867 @default.
• W3022927685 hasConceptScore W3022927685C41091548 @default.
• W3022927685 hasConceptScore W3022927685C502942594 @default.
• W3022927685 hasConceptScore W3022927685C54355233 @default.
• W3022927685 hasConceptScore W3022927685C552990157 @default.
• W3022927685 hasConceptScore W3022927685C55493867 @default.
• W3022927685 hasConceptScore W3022927685C71924100 @default.
• W3022927685 hasConceptScore W3022927685C86803240 @default.
• W3022927685 hasLocation W30229276851 @default.
• W3022927685 hasLocation W30229276852 @default.
• W3022927685 hasOpenAccess W3022927685 @default.
• W3022927685 hasPrimaryLocation W30229276851 @default.
• W3022927685 hasRelatedWork W10662955 @default.
• W3022927685 hasRelatedWork W13212225 @default.
• W3022927685 hasRelatedWork W14586556 @default.
• W3022927685 hasRelatedWork W16537264 @default.

• next