FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3022929032> ?p ?o ?g. }

• W3022929032 endingPage "138" @default.
• W3022929032 startingPage "130" @default.
• W3022929032 abstract "Photodynamic therapy (PDT) is a relatively new therapy that has shown promise for treating various cancers in both preclinical and clinical studies. The present study evaluated the potential use of PET with radiolabeled choline to monitor early tumor response to PDT in animal models.Methods: Two human prostate cancer models (PC-3 and CWR22) were studied in athymic nude mice. A second-generation photosensitizer, phthalocyanine 4 (Pc 4), was delivered to each animal by a tail vein injection 48 h before laser illumination. Small-animal PET images with 11 C-choline were acquired before PDT and at 1, 24, and 48 h after PDT. Time–activity curves of 11 C-choline uptake were analyzed before and after PDT. The percentage of the injected dose per gram of tissue was quantified for both treated and control tumors at each time point. In addition, Pc 4-PDT was performed in cell cultures. Cell viability and 11 C-choline uptake in PDT-treated and control cells were measured. Results: For treated tumors, normalized 11 C-choline uptake decreased significantly 24 and 48 h after PDT, compared with the same tumors before PDT (P , 0.001). For the control tumors, normalized 11 C-choline uptake increased significantly. For mice with CWR22 tumors, the prostate-specific antigen level decreased 24 and 48 h after PDT. Pc 4-PDT in cell culture showed that the treated tumor cells, compared with the control cells, had less than 50% 11 C-choline activity at 5, 30, and 45 min after PDT, whereas the cell viability test showed that the treated cells were viable longer than 7 h after PDT. Conclusion: PET with 11 C-choline is sensitive for detecting early changes associated with Pc 4-PDT in mouse models of human prostate cancer. Choline PET has the potential to determine whether a PDT-treated tumor responds to treatment within 48" @default.
• W3022929032 created "2020-05-13" @default.
• W3022929032 creator A5054513966 @default.
• W3022929032 creator A5055853672 @default.
• W3022929032 creator A5080353358 @default.
• W3022929032 creator A5083707303 @default.
• W3022929032 date "2010-01-01" @default.
• W3022929032 modified "2023-09-23" @default.
• W3022929032 title "Choline PET for Monitoring Early Tumor Response to Photodynamic Therapy" @default.
• W3022929032 cites W1419228847 @default.
• W3022929032 cites W1575864823 @default.
• W3022929032 cites W1750884433 @default.
• W3022929032 cites W1800403003 @default.
• W3022929032 cites W1916661321 @default.
• W3022929032 cites W1963291367 @default.
• W3022929032 cites W1974435095 @default.
• W3022929032 cites W1978809370 @default.
• W3022929032 cites W1989553576 @default.
• W3022929032 cites W2008365299 @default.
• W3022929032 cites W2020232556 @default.
• W3022929032 cites W2023589957 @default.
• W3022929032 cites W2025359238 @default.
• W3022929032 cites W2029070398 @default.
• W3022929032 cites W2033279283 @default.
• W3022929032 cites W2048901783 @default.
• W3022929032 cites W2050681211 @default.
• W3022929032 cites W2051051301 @default.
• W3022929032 cites W2056839504 @default.
• W3022929032 cites W2059558338 @default.
• W3022929032 cites W2065483378 @default.
• W3022929032 cites W2079162542 @default.
• W3022929032 cites W2090455318 @default.
• W3022929032 cites W2094579016 @default.
• W3022929032 cites W2104016885 @default.
• W3022929032 cites W2104739158 @default.
• W3022929032 cites W2121781112 @default.
• W3022929032 cites W2129339346 @default.
• W3022929032 cites W2129485338 @default.
• W3022929032 cites W2139175127 @default.
• W3022929032 cites W2139990463 @default.
• W3022929032 cites W2147323526 @default.
• W3022929032 cites W2151982942 @default.
• W3022929032 cites W2158780563 @default.
• W3022929032 cites W2160072625 @default.
• W3022929032 cites W2161896504 @default.
• W3022929032 cites W2165178187 @default.
• W3022929032 cites W2291545341 @default.
• W3022929032 cites W1978293661 @default.
• W3022929032 cites W2066788797 @default.
• W3022929032 hasPublicationYear "2010" @default.
• W3022929032 type Work @default.
• W3022929032 sameAs 3022929032 @default.
• W3022929032 citedByCount "7" @default.
• W3022929032 countsByYear W30229290322012 @default.
• W3022929032 countsByYear W30229290322013 @default.
• W3022929032 countsByYear W30229290322016 @default.
• W3022929032 countsByYear W30229290322018 @default.
• W3022929032 crossrefType "journal-article" @default.
• W3022929032 hasAuthorship W3022929032A5054513966 @default.
• W3022929032 hasAuthorship W3022929032A5055853672 @default.
• W3022929032 hasAuthorship W3022929032A5080353358 @default.
• W3022929032 hasAuthorship W3022929032A5083707303 @default.
• W3022929032 hasConcept C121608353 @default.
• W3022929032 hasConcept C126322002 @default.
• W3022929032 hasConcept C142724271 @default.
• W3022929032 hasConcept C150903083 @default.
• W3022929032 hasConcept C178790620 @default.
• W3022929032 hasConcept C185592680 @default.
• W3022929032 hasConcept C207001950 @default.
• W3022929032 hasConcept C2780192828 @default.
• W3022929032 hasConcept C2781123555 @default.
• W3022929032 hasConcept C2781323092 @default.
• W3022929032 hasConcept C2781469039 @default.
• W3022929032 hasConcept C502942594 @default.
• W3022929032 hasConcept C71924100 @default.
• W3022929032 hasConcept C86803240 @default.
• W3022929032 hasConceptScore W3022929032C121608353 @default.
• W3022929032 hasConceptScore W3022929032C126322002 @default.
• W3022929032 hasConceptScore W3022929032C142724271 @default.
• W3022929032 hasConceptScore W3022929032C150903083 @default.
• W3022929032 hasConceptScore W3022929032C178790620 @default.
• W3022929032 hasConceptScore W3022929032C185592680 @default.
• W3022929032 hasConceptScore W3022929032C207001950 @default.
• W3022929032 hasConceptScore W3022929032C2780192828 @default.
• W3022929032 hasConceptScore W3022929032C2781123555 @default.
• W3022929032 hasConceptScore W3022929032C2781323092 @default.
• W3022929032 hasConceptScore W3022929032C2781469039 @default.
• W3022929032 hasConceptScore W3022929032C502942594 @default.
• W3022929032 hasConceptScore W3022929032C71924100 @default.
• W3022929032 hasConceptScore W3022929032C86803240 @default.
• W3022929032 hasIssue "1" @default.
• W3022929032 hasLocation W30229290321 @default.
• W3022929032 hasOpenAccess W3022929032 @default.
• W3022929032 hasPrimaryLocation W30229290321 @default.
• W3022929032 hasRelatedWork W1000429366 @default.
• W3022929032 hasRelatedWork W1485724755 @default.
• W3022929032 hasRelatedWork W1953097040 @default.
• W3022929032 hasRelatedWork W1963947413 @default.

• next