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- W3022955034 endingPage "118" @default.
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- W3022955034 abstract "Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells. In humans, genetic mutations, pathologies, certain medical treatments, and aging, result in CoQ deficiencies, which are linked to mitochondrial, cardiovascular, and neurodegenerative diseases. The only strategy available for these patients is CoQ supplementation. CoQ supplements benefit a small subset of patients, but the poor solubility of CoQ greatly limits treatment efficacy. Consequently, the efficient delivery of CoQ to the mitochondria and restoration of respiratory function remains a major challenge. A better understanding of CoQ uptake and mitochondrial delivery is crucial to make this molecule a more efficient and effective therapeutic tool. In this study, we investigated the mechanism of CoQ uptake and distribution using the yeast Saccharomyces cerevisiae as a model organism. The addition of exogenous CoQ was tested for the ability to restore growth on non-fermentable medium in several strains that lack CoQ synthesis (coq mutants). Surprisingly, we discovered that the presence of CoQ biosynthetic intermediates impairs assimilation of CoQ into a functional respiratory chain in yeast cells. Moreover, a screen of 40 gene deletions considered to be candidates to prevent exogenous CoQ from rescuing growth of the CoQ-less coq2Δ mutant, identified six novel genes (CDC10, RTS1, RVS161, RVS167, VPS1, and NAT3) as necessary for efficient trafficking of CoQ to mitochondria. The proteins encoded by these genes represent essential steps in the pathways responsible for transport of exogenously supplied CoQ to its functional sites in the cell, and definitively associate CoQ distribution with endocytosis and intracellular vesicular trafficking pathways conserved from yeast to human cells." @default.
- W3022955034 created "2020-05-13" @default.
- W3022955034 creator A5013520775 @default.
- W3022955034 creator A5021812477 @default.
- W3022955034 creator A5023674720 @default.
- W3022955034 creator A5035598669 @default.
- W3022955034 creator A5044989399 @default.
- W3022955034 creator A5049703771 @default.
- W3022955034 creator A5053230113 @default.
- W3022955034 creator A5062511010 @default.
- W3022955034 date "2020-07-01" @default.
- W3022955034 modified "2023-10-18" @default.
- W3022955034 title "Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae" @default.
- W3022955034 cites W1225989448 @default.
- W3022955034 cites W1529325163 @default.
- W3022955034 cites W1815576116 @default.
- W3022955034 cites W1932367267 @default.
- W3022955034 cites W1965634593 @default.
- W3022955034 cites W1966477752 @default.
- W3022955034 cites W1967433085 @default.
- W3022955034 cites W1970042877 @default.
- W3022955034 cites W1988303786 @default.
- W3022955034 cites W1988476536 @default.
- W3022955034 cites W1995210626 @default.
- W3022955034 cites W1997873957 @default.
- W3022955034 cites W2007098042 @default.
- W3022955034 cites W2008206202 @default.
- W3022955034 cites W2009051079 @default.
- W3022955034 cites W2010524294 @default.
- W3022955034 cites W2012180656 @default.
- W3022955034 cites W2020349697 @default.
- W3022955034 cites W2026905117 @default.
- W3022955034 cites W2027351026 @default.
- W3022955034 cites W2032713387 @default.
- W3022955034 cites W2036512300 @default.
- W3022955034 cites W2037747220 @default.
- W3022955034 cites W2040937769 @default.
- W3022955034 cites W2041724231 @default.
- W3022955034 cites W2043830456 @default.
- W3022955034 cites W2049402673 @default.
- W3022955034 cites W2049516586 @default.
- W3022955034 cites W2053839218 @default.
- W3022955034 cites W2055003211 @default.
- W3022955034 cites W2059456698 @default.
- W3022955034 cites W2062507791 @default.
- W3022955034 cites W2062838202 @default.
- W3022955034 cites W2064129745 @default.
- W3022955034 cites W2064681361 @default.
- W3022955034 cites W2066029883 @default.
- W3022955034 cites W2068699146 @default.
- W3022955034 cites W207868421 @default.
- W3022955034 cites W2080408951 @default.
- W3022955034 cites W2083258595 @default.
- W3022955034 cites W2088780434 @default.
- W3022955034 cites W2092143550 @default.
- W3022955034 cites W2100430785 @default.
- W3022955034 cites W2101694619 @default.
- W3022955034 cites W2103096171 @default.
- W3022955034 cites W2104356874 @default.
- W3022955034 cites W2106252068 @default.
- W3022955034 cites W2110380412 @default.
- W3022955034 cites W2111472436 @default.
- W3022955034 cites W2111819694 @default.
- W3022955034 cites W2120811558 @default.
- W3022955034 cites W2125140996 @default.
- W3022955034 cites W2126096987 @default.
- W3022955034 cites W2127654123 @default.
- W3022955034 cites W2128090246 @default.
- W3022955034 cites W2130974873 @default.
- W3022955034 cites W2136620344 @default.
- W3022955034 cites W2141026950 @default.
- W3022955034 cites W2144866481 @default.
- W3022955034 cites W2164298973 @default.
- W3022955034 cites W2169333620 @default.
- W3022955034 cites W2169706900 @default.
- W3022955034 cites W2221807981 @default.
- W3022955034 cites W2239384431 @default.
- W3022955034 cites W2258667459 @default.
- W3022955034 cites W2258692416 @default.
- W3022955034 cites W2320250547 @default.
- W3022955034 cites W2335798953 @default.
- W3022955034 cites W2337893060 @default.
- W3022955034 cites W2468528373 @default.
- W3022955034 cites W2475321261 @default.
- W3022955034 cites W2498084078 @default.
- W3022955034 cites W2546939430 @default.
- W3022955034 cites W2547739050 @default.
- W3022955034 cites W2603773384 @default.
- W3022955034 cites W2615274244 @default.
- W3022955034 cites W2617190377 @default.
- W3022955034 cites W2624028232 @default.
- W3022955034 cites W2746038414 @default.
- W3022955034 cites W2754373993 @default.
- W3022955034 cites W2760102497 @default.
- W3022955034 cites W2772243888 @default.
- W3022955034 cites W2774418789 @default.
- W3022955034 cites W2792617348 @default.
- W3022955034 cites W2794304138 @default.