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- W3022974772 abstract "The existence of specific binding sites for benzodiazepines has led to the discovery of endogenous ligands for benzodiazepine receptors that are collectively designated by the term endozepines. In the brain and in peripheral nervous tissues, endozepines are exclusively expressed by glial cells. The release of endozepines from cultured astrocytes is finely regulated by neurotransmitters and neuropeptides. Endozepines exert their effects either through classical central- and peripheral-type benzodiazepine receptors or through G-protein-coupled receptors. Intracerebroventricular injection of endozepines causes marked effects on anxiety, sleep, and food consumption. The concentration of endozepines in the brain and cerebrospinal fluid is affected in various diseases, including depression and hepatic encephalopathy." @default.
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- W3022974772 date "2006-01-01" @default.
- W3022974772 modified "2023-09-25" @default.
- W3022974772 title "Endozepines" @default.
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- W3022974772 doi "https://doi.org/10.1016/b978-012369442-3/50114-8" @default.
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