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- W3022984886 abstract "Addition of nitrite achieves kill of micro-organisms where acid alone allows growth to continue. The synergism in antimicrobial action of acid and nitrite is evident against common gut pathogens such as the Enterobacteriaceae, including Escherichia coli 0157, but also against the stomach pathogen Helicobacter pylori, normally very resistant to acid alone. The antibacterial action of acidified nitrite becomes apparent at physiological concentrations of acid and nitrite after exposure times that are within the passage time of a food bolus through the stomach. The antimicrobial activity of acidified nitrite is enhanced by thiocyanate, also present in gastric juice. Ascorbic acid provides protection against the antibacterial action of acidified nitrite, suggesting that NO is not the antibacterial agent.The mechanism of chemical host defence via acidification of salivary nitrite may be of fundamental importance. A conclusive demonstration of the antimicrobial effect in vivo would require a major re-interpretation of the role of dietary nitrate in human health and animal husbandry." @default.
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- W3022984886 date "1999-01-01" @default.
- W3022984886 modified "2023-09-27" @default.
- W3022984886 title "Antimicrobial Effect of Acidified Nitrite on Gut Pathogens: the Importance of Dietary Nitrate in Host Defence" @default.
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- W3022984886 doi "https://doi.org/10.1533/9781845693206.295" @default.
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