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• W3022984980 endingPage "237" @default.
• W3022984980 startingPage "220" @default.
• W3022984980 abstract "The nervous and immune systems are known to communicate with each other to influence each other’s function. A role for such a bidirectional communication in helping to maintain homeostasis is becoming well established. However, any type of miscommunication between the two systems and its relevance in mediating the development and/or progression of a disease state remains inconclusive and understudied. The latter limitation is complicated further when one considers that the nervous and immune systems are often studied as separate disciplines, which contributes much to an understanding of how each system functions autonomously, but not to an understanding of how a communication between the two systems might be relevant clinically. This article will review the evidence supporting the existence of a functional line of communication between the sympathetic nervous system and the immune system, with a particular emphasis on the role of the neurotransmitter norepinephrine and immune cell-derived cytokines in modulating immune and nervous system function, respectively. This article will also discuss some possibilities as to how a toxicant might target this neuroimmune communication to potentially affect immune responsiveness, contribute to a disruption in homeostasis, and subsequently contribute to the possible development of clinical disease, without ever directly affecting any cells of the immune system itself." @default.
• W3022984980 created "2020-05-13" @default.
• W3022984980 creator A5014930847 @default.
• W3022984980 date "2018-01-01" @default.
• W3022984980 modified "2023-09-27" @default.
• W3022984980 title "Neuroimmunology" @default.
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