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- W3022998913 endingPage "2585" @default.
- W3022998913 startingPage "2559" @default.
- W3022998913 abstract "Abstract Early identification of toxicity associated with new chemical entities (NCEs) is critical in preventing late-stage drug development attrition. Liver injury remains a leading cause of drug failures in clinical trials and post-approval withdrawals reflecting the poor translation between traditional preclinical animal models and human clinical outcomes. For this reason, preclinical strategies have evolved over recent years to incorporate more sophisticated human in vitro cell-based models with multi-parametric endpoints. This review aims to highlight the evolution of the strategies adopted to improve human hepatotoxicity prediction in drug discovery and compares/contrasts these with recent activities in our lab. The key role of human exposure and hepatic drug uptake transporters (e.g. OATPs, OAT2) is also elaborated." @default.
- W3022998913 created "2020-05-13" @default.
- W3022998913 creator A5000400718 @default.
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- W3022998913 creator A5023443760 @default.
- W3022998913 creator A5036081621 @default.
- W3022998913 creator A5079424977 @default.
- W3022998913 date "2020-05-06" @default.
- W3022998913 modified "2023-10-16" @default.
- W3022998913 title "The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development" @default.
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