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• W3023003065 abstract "Clumped cells are generally more dangerous than single cells in cancer spread, thrombocytosis and biofilm infectivity. Here a simple direct kinetic assay is used to examine a specific reagent for anti-clumping activity using a Prefer fixed yeast (Saccharomyces cerevisiae) model that has been recently described by us in detail using other reagents. In 1212 trials by 17 investigators sodium sulfate (1-3 mg per ml deionized water) was examined by measuring percentage single cells, number of clumps and number of cells per clump over a 60 min time course, with standard deviations and t-tests to determine any significant differences between controls and experimentals. Sodium sulfate showed sometimes inconsistent unclumping activity especially in magnitude of effects. When percentage of single cells increased, clump number and/or number of cells per clump generally decreased, helping to validate the assay. An example of these findings in 60 trials at 60 min with 1-3 mg sodium sulfate per ml deionized water: 1 mg 15% increased singles (p<0.01), 29% decreased clumps (p<0.01), 11% decreased cells per clump (p>0.05); 2 mg 12% increased singles (p<0.01), 20% decreased clumps (p<0.01), 30% decreased cells per clump (p<0.01); 3 mg 27% increased singles (p<0.01), 36% decreased clumps (p<0.01), 28% decreased cells per clump (p<0.02). Here sodium sulfate showed promise as an anti-cell-clumping reagent together with sodium citrate reported previously in part 1 of this study. Sodium citrate is a known human anticoagulant independently identified with this assay, helping to validate the assay for drug discovery applications." @default.
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• W3023003065 date "2020-01-01" @default.
• W3023003065 modified "2023-09-26" @default.
• W3023003065 title "A Kinetic Assay for Drug Discovery: Part 2, Sodium Sulfate" @default.
• W3023003065 doi "https://doi.org/10.11648/j.ajasr.20200602.12" @default.
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