Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023034628> ?p ?o ?g. }
- W3023034628 endingPage "421" @default.
- W3023034628 startingPage "409" @default.
- W3023034628 abstract "Parathyroid carcinoma is a rare endocrine neoplasm, usually causing severe primary hyperparathyroidism, that frequently causes death from unmanageable hypercalcemia. At times, the diagnosis can be difficult. Currently, the pathological diagnosis of parathyroid carcinoma is restricted to lesions showing unequivocal growth into adjacent tissues or metastasis. Inactivating mutations of CDC73 gene have been identified in up to 70% of apparently sporadic parathyroid carcinomas and up to one-third of cases had germline mutations. Loss of parafibromin expression on immunohistochemistry has been found in the majority of parathyroid carcinomas. The presence of both CDC73 mutations and loss of parafibromin seems to predict a worse clinical outcome and a lower overall 5- and 10-year survival. The treatment of choice is the en bloc resection of the tumor, which should be performed in all patients with clinical suspicion of parathyroid cancer. The course of parathyroid carcinoma is variable and patients may have local recurrences or distant metastases." @default.
- W3023034628 created "2020-05-13" @default.
- W3023034628 creator A5059759496 @default.
- W3023034628 creator A5081755951 @default.
- W3023034628 date "2015-01-01" @default.
- W3023034628 modified "2023-09-30" @default.
- W3023034628 title "Parathyroid Carcinoma" @default.
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