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- W3023073886 endingPage "275" @default.
- W3023073886 startingPage "233" @default.
- W3023073886 abstract "Insects are the most significant vectors of human disease. Disease-transmitting insects often rely on vertebrate blood (haematophagy) either as a sole food source or as a significant component of their diet. While blood is a nutrient-rich resource, it also lacks key vitamins necessary for host development. Many insects which feed obligately on blood rely on bacterial symbionts to overcome this dietary limitation. Microbes associated with vectors have also been demonstrated to play essential roles in host development, immune system modulation, and vector competency. These microbes range from irreversibly specialized symbionts that are vertically transmitted from mother to offspring, to facultatively symbiotic, free-living microbes acquired from the local environment. Some may be found at variable frequencies and yet still shape numerous aspects of host physiology. Here we focus our attention on three groups of insect disease vectors and their varied associations with symbiotic microbes. This review will examine tsetse flies (Glossina), vectors of Trypanosoma species responsible for human and animal African trypanosomiasis, kissing bugs (Triatominae), the vectors of T. cruzi that causes Chagas’ disease, and mosquitoes (Culicidae), vectors of a wide array of pathogens from Plasmodium to arboviruses. We explore the rapidly growing understanding of how microbes contribute to the development, physiology, and pathogen transmission of these insects." @default.
- W3023073886 created "2020-05-13" @default.
- W3023073886 creator A5013468867 @default.
- W3023073886 creator A5087165573 @default.
- W3023073886 date "2020-01-01" @default.
- W3023073886 modified "2023-10-02" @default.
- W3023073886 title "Functions and mechanisms of symbionts of insect disease vectors" @default.
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