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• W3023075859 abstract "Most drug molecules are ionizable in aqueous solutions. Ionization occurs when the molecules acquire or lose hydrogen ions in response to changes in the pH of the solution. This chapter reviews the theory of solution equilibria, which explains the behavior of ionizable molecules in solution, and describes the structural features of organic molecules that cause them to become ionized. It then discusses the importance of drug ionization, before moving on to consider the measurement of ionization constants, and techniques for predicting them by studying molecular structure." @default.
• W3023075859 created "2020-05-13" @default.
• W3023075859 creator A5068954602 @default.
• W3023075859 date "2007-01-01" @default.
• W3023075859 modified "2023-10-17" @default.
• W3023075859 title "Ionization Constants and Ionization Profiles" @default.
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• W3023075859 doi "https://doi.org/10.1016/b0-08-045044-x/00133-4" @default.
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