Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023082015> ?p ?o ?g. }
- W3023082015 endingPage "606" @default.
- W3023082015 startingPage "601" @default.
- W3023082015 abstract "Facioscapulohumeral muscular dystrophy (FSHD), a dominantly inherited disorder, is the third most common dystrophy after Duchenne and myotonic muscular dystrophy. No known effective treatments exist for FSHD. The lack of an understanding of the underlying pathophysiology remains an obstacle in the development of targeted therapeutic interventions. The genetic defect is a loss of a critical number of a repetitive element (D4Z4) in the 4q subtelomeric region. The loss of the repeats results in specific changes in chromatin structure, although neither the molecular nor the cellular consequences of this change are known. Nevertheless, these epigenetic changes in chromatin structure offer a potential therapeutic target. This review discusses current management strategies in FSHD as well as potential therapeutic interventions to slow down or reverse the progressive muscle atrophy and weakness." @default.
- W3023082015 created "2020-05-13" @default.
- W3023082015 creator A5000968184 @default.
- W3023082015 date "2008-10-01" @default.
- W3023082015 modified "2023-10-08" @default.
- W3023082015 title "Facioscapulohumeral muscular dystrophy" @default.
- W3023082015 cites W1523155803 @default.
- W3023082015 cites W1585934453 @default.
- W3023082015 cites W1966805460 @default.
- W3023082015 cites W1973306657 @default.
- W3023082015 cites W1974256573 @default.
- W3023082015 cites W1975360343 @default.
- W3023082015 cites W1981750006 @default.
- W3023082015 cites W1991105138 @default.
- W3023082015 cites W1993726589 @default.
- W3023082015 cites W1993759560 @default.
- W3023082015 cites W1996897725 @default.
- W3023082015 cites W2001004724 @default.
- W3023082015 cites W2002551825 @default.
- W3023082015 cites W2005286540 @default.
- W3023082015 cites W2010580448 @default.
- W3023082015 cites W2011347485 @default.
- W3023082015 cites W2013312420 @default.
- W3023082015 cites W2013560484 @default.
- W3023082015 cites W2014889497 @default.
- W3023082015 cites W2016990566 @default.
- W3023082015 cites W2026431435 @default.
- W3023082015 cites W2028447788 @default.
- W3023082015 cites W2029445074 @default.
- W3023082015 cites W2034496569 @default.
- W3023082015 cites W2037577079 @default.
- W3023082015 cites W2047284298 @default.
- W3023082015 cites W2056307417 @default.
- W3023082015 cites W2059330693 @default.
- W3023082015 cites W2065335605 @default.
- W3023082015 cites W2068257793 @default.
- W3023082015 cites W2072133436 @default.
- W3023082015 cites W2080615283 @default.
- W3023082015 cites W2082127114 @default.
- W3023082015 cites W2085638799 @default.
- W3023082015 cites W2088292638 @default.
- W3023082015 cites W2093215742 @default.
- W3023082015 cites W2096643396 @default.
- W3023082015 cites W2097010829 @default.
- W3023082015 cites W2113144753 @default.
- W3023082015 cites W2116284747 @default.
- W3023082015 cites W2117127174 @default.
- W3023082015 cites W2118562875 @default.
- W3023082015 cites W2153414043 @default.
- W3023082015 cites W2156315449 @default.
- W3023082015 cites W2160995049 @default.
- W3023082015 cites W2161098433 @default.
- W3023082015 cites W2162440278 @default.
- W3023082015 cites W2163868680 @default.
- W3023082015 cites W2166015861 @default.
- W3023082015 cites W2166236066 @default.
- W3023082015 cites W2166485013 @default.
- W3023082015 cites W2171106093 @default.
- W3023082015 cites W2176996109 @default.
- W3023082015 cites W2244258398 @default.
- W3023082015 cites W2328707090 @default.
- W3023082015 cites W4236625738 @default.
- W3023082015 cites W4247340781 @default.
- W3023082015 cites W4300579313 @default.
- W3023082015 doi "https://doi.org/10.1016/j.nurt.2008.07.005" @default.
- W3023082015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2628543" @default.
- W3023082015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19019312" @default.
- W3023082015 hasPublicationYear "2008" @default.
- W3023082015 type Work @default.
- W3023082015 sameAs 3023082015 @default.
- W3023082015 citedByCount "104" @default.
- W3023082015 countsByYear W30230820152012 @default.
- W3023082015 countsByYear W30230820152013 @default.
- W3023082015 countsByYear W30230820152014 @default.
- W3023082015 countsByYear W30230820152015 @default.
- W3023082015 countsByYear W30230820152016 @default.
- W3023082015 countsByYear W30230820152017 @default.
- W3023082015 countsByYear W30230820152018 @default.
- W3023082015 countsByYear W30230820152019 @default.
- W3023082015 countsByYear W30230820152020 @default.
- W3023082015 countsByYear W30230820152021 @default.
- W3023082015 countsByYear W30230820152022 @default.
- W3023082015 countsByYear W30230820152023 @default.
- W3023082015 crossrefType "journal-article" @default.
- W3023082015 hasAuthorship W3023082015A5000968184 @default.
- W3023082015 hasBestOaLocation W30230820152 @default.
- W3023082015 hasConcept C104317684 @default.
- W3023082015 hasConcept C105702510 @default.
- W3023082015 hasConcept C169760540 @default.
- W3023082015 hasConcept C2776418732 @default.
- W3023082015 hasConcept C2778063965 @default.
- W3023082015 hasConcept C2779030066 @default.
- W3023082015 hasConcept C2779981540 @default.
- W3023082015 hasConcept C41091548 @default.
- W3023082015 hasConcept C54355233 @default.
- W3023082015 hasConcept C60644358 @default.
- W3023082015 hasConcept C71924100 @default.
- W3023082015 hasConcept C83640560 @default.