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- W3023083630 endingPage "391" @default.
- W3023083630 startingPage "357" @default.
- W3023083630 abstract "Abstract Protease therapy is the backbone of enzymatic debridement of chronic wounds. It helps digest the slough, biofilm, and eschar, which aids in restarting the wound-healing process in a clinically and cost-effective manner. Currently, one of the six described protease therapies, Clostridial collagenase ointment (CCO), is FDA approved for enzymatic debridement of chronic wounds, including diabetic foot ulcers (DFUs). Protease therapy is beneficial for the treatment of stalled acute and chronic wounds, such as DFUs, surgical wounds, venous leg ulcers, and burns. Mechanistic studies revealed that Clostridial collagenase liberates bioactive peptides from parent structural and extracellular matrix-associated molecules, which augment angiogenesis, granulation, and epithelialization. Protease therapy also modulates the proinflammatory macrophages in the inflammatory phase, which fosters a transition to a healing phenotype while supporting proliferation, epithelialization, and wound closure. This review also discusses current developments of plant-based protease therapies and accompanying or emerging therapeutics." @default.
- W3023083630 created "2020-05-13" @default.
- W3023083630 creator A5077822196 @default.
- W3023083630 creator A5086968719 @default.
- W3023083630 creator A5089516592 @default.
- W3023083630 date "2020-01-01" @default.
- W3023083630 modified "2023-09-23" @default.
- W3023083630 title "Protease technology in wound repair" @default.
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