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- W3023083854 abstract "Mitsugumin 53 (MG53) is a protein essential in cellular membrane repair. It facilitates the nucleation of intracellular vesicles to sites of membrane disruption to create repair patches, contributing to the regenerative capacity of striated muscles upon injury. A member of the TRIM protein family, MG53 is also an E3 ligase to down-regulation insulin receptor substrate-1 (IRS-1) in insulin signaling. A study indicated this property of MG53 as problematic in the development of metabolic syndrome. In light of this discussion, we decided to investigate the effect of metabolic disorders on MG53 activity. Immunoblotting showed that MG53 expression is not altered within the striated muscles of mice exhibiting metabolic syndrome. However, we found that metabolic stress actually reduced MG53 levels in blood circulation. It has been established that diabetic patients exhibit inadequate tissue repair aptitude and the diminished circulating MG53 observed may explain this phenomenon. Furthermore, immunohistochemical analyses reveal that skeletal muscle fibers of mice with metabolic disorders experience localization of intracellular MG53 around mitochondria. This clustering may represent an adaptive response to metabolic stress and may implicate MG53 as a guardian to protect exhausted mitochondria. Overall, our study advocates for an elevation of MG53 expression in muscle tissues and therapeutic approaches to accomplishing this task may be a novel method to treat metabolic diseases with tissue repair defects." @default.
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- W3023083854 date "2015-04-01" @default.
- W3023083854 modified "2023-09-27" @default.
- W3023083854 title "Effect of Metabolic Syndrome on Mitsugumin 53 Expression and Function" @default.
- W3023083854 doi "https://doi.org/10.1096/fasebj.29.1_supplement.801.7" @default.
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