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- W3023084908 abstract "Background The specific disease, intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy-complication. However, there are no indications for ICP in the domestic licenced drugs for protecting the liver and reducing bile acid levels, which are often based on evidence-based medicine or evidence-based pharmacy to select drugs that have been used during pregnancy and have no teratogenic evidence. Methods By analyzing the drug use (Reduced glutathione for injection, Inosine injection and Ursodeoxycholic acid tablets) and the allergic reactions in the clinical practice in a rare patient with hepatic disorders in third trimester of pregnancy, in order to remind clinicians that in the course of using hepatoprotective and bile acid-lowering drugs, their current clinical practice was not always safety. Especially when using two or more hepatoprotective drugs, should pay more attention to whether it will aggravate the risk of adverse reactions or even allergic reactions. Results Based on the literature reports and the corresponding drug instructions, it is concluded that all three drugs might cause allergic reactions, but there are few reports of allergic reactions caused by ursodeoxycholic acid tablets. So far, there have been no reports of two allergic reactions for three drugs in the same patient in a short period. In this case, we judged that the first allergic reaction was caused by reduced glutathione for injection, and the second allergic reaction was caused by inosine injection, but the combination of ursodeoxycholic acid tablets may aggravate the allergic reaction. Conclusions 1. Reduced glutathione for injection may lead to severe allergic reactions in women in the third trimester of pregnancy. 2. Ursodeoxycholic acid tablets may aggravate the risk of allergic reactions for inosine injection when combined with both drugs is used to protect liver and reduce bile acid levels in women in the third trimester of pregnancy." @default.
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- W3023084908 date "2019-06-01" @default.
- W3023084908 modified "2023-09-24" @default.
- W3023084908 title "IDDF2019-ABS-0032 The analysis of the allergic reaction of women in the third trimester of pregnancy induced by reduced glutathione for injection and inosine injection successively" @default.
- W3023084908 doi "https://doi.org/10.1136/gutjnl-2019-iddfabstracts.245" @default.
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