Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023086712> ?p ?o ?g. }
- W3023086712 endingPage "379" @default.
- W3023086712 startingPage "361" @default.
- W3023086712 abstract "This chapter reviews the pathophysiological mechanisms leading to development of chronic obstructive pulmonary disease (COPD). The chapter focuses on the role of specific cells and mediators on which the COPD process is based. COPD is a clinical single entity that includes a collection of disorders sharing the common physiological feature of progressively worsening expiratory airflow limitation. The various conditions included under COPD have different risk factors and pathophysiological mechanisms. Airflow limitation in COPD results from several distinct lesions. The decrease in intraluminal pressure and the loss of adjacent alveoli in emphysema lead to the collapse of small airways and thus limit expiratory airflow. Peribronchial fibrosis can also lead to fixed airflow limitation by narrowing the small airways. Thus, these two lesions interact functionally to exacerbate the further reduced expiratory flows. Patients with COPD also have a variety of additional nonpulmonary problems, which often affect the clinical course. These include lung cancer, skeletal muscle dysfunction, osteoporosis, bone fracture, and an increased incidence of cardiac mortality." @default.
- W3023086712 created "2020-05-13" @default.
- W3023086712 creator A5083270547 @default.
- W3023086712 date "2002-01-01" @default.
- W3023086712 modified "2023-10-14" @default.
- W3023086712 title "Pathogenesis of COPD" @default.
- W3023086712 cites W1497357697 @default.
- W3023086712 cites W1522434247 @default.
- W3023086712 cites W1571619727 @default.
- W3023086712 cites W1690452867 @default.
- W3023086712 cites W1747867097 @default.
- W3023086712 cites W17555875 @default.
- W3023086712 cites W1793308124 @default.
- W3023086712 cites W1824777861 @default.
- W3023086712 cites W185736790 @default.
- W3023086712 cites W1892949664 @default.
- W3023086712 cites W1921570699 @default.
- W3023086712 cites W1929767227 @default.
- W3023086712 cites W1966224713 @default.
- W3023086712 cites W1968123003 @default.
- W3023086712 cites W1968272735 @default.
- W3023086712 cites W1972556193 @default.
- W3023086712 cites W1974431676 @default.
- W3023086712 cites W1975409057 @default.
- W3023086712 cites W1978330686 @default.
- W3023086712 cites W1983344336 @default.
- W3023086712 cites W1985007677 @default.
- W3023086712 cites W1985527057 @default.
- W3023086712 cites W1986142113 @default.
- W3023086712 cites W1990674750 @default.
- W3023086712 cites W1992332490 @default.
- W3023086712 cites W1992697535 @default.
- W3023086712 cites W1992940048 @default.
- W3023086712 cites W1993774985 @default.
- W3023086712 cites W1995902693 @default.
- W3023086712 cites W1996214993 @default.
- W3023086712 cites W1996753343 @default.
- W3023086712 cites W1997631109 @default.
- W3023086712 cites W1998218749 @default.
- W3023086712 cites W2000384489 @default.
- W3023086712 cites W2000498200 @default.
- W3023086712 cites W2003646746 @default.
- W3023086712 cites W2003763810 @default.
- W3023086712 cites W2003783610 @default.
- W3023086712 cites W2003851888 @default.
- W3023086712 cites W2004065539 @default.
- W3023086712 cites W2007222830 @default.
- W3023086712 cites W2008235942 @default.
- W3023086712 cites W2008326806 @default.
- W3023086712 cites W2011704466 @default.
- W3023086712 cites W2016506678 @default.
- W3023086712 cites W2020063404 @default.
- W3023086712 cites W2020525780 @default.
- W3023086712 cites W2020852059 @default.
- W3023086712 cites W2021095654 @default.
- W3023086712 cites W2022656206 @default.
- W3023086712 cites W2022821656 @default.
- W3023086712 cites W2024182441 @default.
- W3023086712 cites W2027998544 @default.
- W3023086712 cites W2028504820 @default.
- W3023086712 cites W2029006169 @default.
- W3023086712 cites W2030990562 @default.
- W3023086712 cites W2031073883 @default.
- W3023086712 cites W2031172598 @default.
- W3023086712 cites W2031479986 @default.
- W3023086712 cites W2033248720 @default.
- W3023086712 cites W2033380992 @default.
- W3023086712 cites W2036327819 @default.
- W3023086712 cites W2037490315 @default.
- W3023086712 cites W2038897809 @default.
- W3023086712 cites W2039721686 @default.
- W3023086712 cites W2040084626 @default.
- W3023086712 cites W2040338567 @default.
- W3023086712 cites W2040861245 @default.
- W3023086712 cites W2044081787 @default.
- W3023086712 cites W2044803705 @default.
- W3023086712 cites W2045616259 @default.
- W3023086712 cites W2046470493 @default.
- W3023086712 cites W2048906072 @default.
- W3023086712 cites W2052161504 @default.
- W3023086712 cites W2052271236 @default.
- W3023086712 cites W2054350954 @default.
- W3023086712 cites W2058505955 @default.
- W3023086712 cites W2058899783 @default.
- W3023086712 cites W2059483175 @default.
- W3023086712 cites W2059828719 @default.
- W3023086712 cites W2060292420 @default.
- W3023086712 cites W2063945670 @default.
- W3023086712 cites W2064864590 @default.
- W3023086712 cites W2065149104 @default.
- W3023086712 cites W2065496745 @default.
- W3023086712 cites W2065528952 @default.
- W3023086712 cites W2066247603 @default.
- W3023086712 cites W2066829964 @default.
- W3023086712 cites W2066880035 @default.
- W3023086712 cites W2068789291 @default.
- W3023086712 cites W2069009917 @default.
- W3023086712 cites W2069141143 @default.