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• W3023114491 abstract "Publisher SummaryThis chapter discusses the biosynthesis of the prostaglandins. The enzyme system that catalyzes the conversion of polyunsaturated fatty acids to prostaglandins has been named prostaglandin synthetase. It is found in many tissues but a particularly rich source is the sheep vesicular gland, homogenates of which were formerly used for the large-scale production of prostaglandins. The biosynthetic pathway for PGA1 and PGA2 has not yet been elucidated, although the formation of PGA1 has been reported during incubation of 8, 11, 14-eicosatrienoic acid with sheep seminal vesicles. The facility with which these compounds can be derived chemically from PGE1 and PGE2 suggests the possibility that PGA compounds are formed by an enzymatically-catalyzed dehydration of PGE compounds. Prostaglandin-like substances are also released in response to adrenergic nerve stimulation or catecholamines from frog skin, rat diaphragm, and cat spleen. There is substantial evidence that prostaglandins of the E series not only act presynaptically to inhibit noradrenaline release but also postsynaptically. Such interactions are complex and vary greatly from one tissue to another." @default.
• W3023114491 created "2020-05-13" @default.
• W3023114491 creator A5085630116 @default.
• W3023114491 date "1974-01-01" @default.
• W3023114491 modified "2023-09-26" @default.
• W3023114491 title "The Prostaglandins" @default.
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