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- W3023116476 abstract "Osteoporosis is a systemic skeletal disease. It is characterized by a disbalance of bone formation and bone resorption. It is treated by escalating steps of drug therapy. This influences bone density. However, therapies for fractures in osteoporotic patients are typically surgical without really treating the osteoporotic phenotype locally. Several possibilities exist. Some drugs used for systemic therapy can be administered locally to the defect space using drug delivery systems. Other local therapies have been applied to fracture and nonunion treatments. An important asset are stem cells that can be obtained from the bone marrow or adipose tissue. A more complete form including natural extracellular matrix and supporting cells is constituted by a reamer-irrigator-aspirator. Finally, an innovative possibility is taking molecular biology techniques into consideration. Osteoporotic fractures have a specific microRNA signature. These upregulated microRNAs can be counteracted by antagomirs. Using them, a broad range of effector messenger RNAs and thus proteins can be modulated. In summary, treatment of osteoporotic fractures should take the osteoporotic pathogenetic pathways into consideration for locally treating and accelerating fracture healing." @default.
- W3023116476 created "2020-05-13" @default.
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- W3023116476 date "2020-04-28" @default.
- W3023116476 modified "2023-10-17" @default.
- W3023116476 title "Can we accelerate the osteoporotic bone fracture healing response?" @default.
- W3023116476 cites W2069811152 @default.
- W3023116476 doi "https://doi.org/10.1201/9780429161087-16" @default.
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