Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023133686> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3023133686 abstract "Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies. However, the use of viruses encoding the reprogramming factors represents a major limitation of the current technology since even low vector expression may alter the differentiation potential of the iPSCs or induce malignant transformation. Here, we show that fibroblasts from five patients with idiopathic Parkinson's disease can be efficiently reprogrammed and subsequently differentiated into dopaminergic neurons. Moreover, we derived hiPSCs free of reprogramming factors using Cre-recombinase excisable viruses. Factor-free hiPSCs maintain a pluripotent state and show a global gene expression profile, more closely related to hESCs than to hiPSCs carrying the transgenes. Our results indicate that residual transgene expression in virus-carrying hiPSCs can affect their molecular characteristics and that factor-free hiPSCs therefore represent a more suitable source of cells for modeling of human disease." @default.
- W3023133686 created "2020-05-13" @default.
- W3023133686 creator A5002145049 @default.
- W3023133686 creator A5006533757 @default.
- W3023133686 creator A5013565839 @default.
- W3023133686 creator A5016304201 @default.
- W3023133686 creator A5029538901 @default.
- W3023133686 creator A5030456420 @default.
- W3023133686 creator A5030851562 @default.
- W3023133686 creator A5045835078 @default.
- W3023133686 creator A5058850275 @default.
- W3023133686 creator A5066738691 @default.
- W3023133686 creator A5070152031 @default.
- W3023133686 creator A5087185533 @default.
- W3023133686 date "2009-03-01" @default.
- W3023133686 modified "2023-09-26" @default.
- W3023133686 title "Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors" @default.
- W3023133686 hasPublicationYear "2009" @default.
- W3023133686 type Work @default.
- W3023133686 sameAs 3023133686 @default.
- W3023133686 citedByCount "0" @default.
- W3023133686 crossrefType "book-chapter" @default.
- W3023133686 hasAuthorship W3023133686A5002145049 @default.
- W3023133686 hasAuthorship W3023133686A5006533757 @default.
- W3023133686 hasAuthorship W3023133686A5013565839 @default.
- W3023133686 hasAuthorship W3023133686A5016304201 @default.
- W3023133686 hasAuthorship W3023133686A5029538901 @default.
- W3023133686 hasAuthorship W3023133686A5030456420 @default.
- W3023133686 hasAuthorship W3023133686A5030851562 @default.
- W3023133686 hasAuthorship W3023133686A5045835078 @default.
- W3023133686 hasAuthorship W3023133686A5058850275 @default.
- W3023133686 hasAuthorship W3023133686A5066738691 @default.
- W3023133686 hasAuthorship W3023133686A5070152031 @default.
- W3023133686 hasAuthorship W3023133686A5087185533 @default.
- W3023133686 hasConcept C102230213 @default.
- W3023133686 hasConcept C104317684 @default.
- W3023133686 hasConcept C107459253 @default.
- W3023133686 hasConcept C134305767 @default.
- W3023133686 hasConcept C145103041 @default.
- W3023133686 hasConcept C1491633281 @default.
- W3023133686 hasConcept C2910924664 @default.
- W3023133686 hasConcept C32470452 @default.
- W3023133686 hasConcept C40767141 @default.
- W3023133686 hasConcept C54355233 @default.
- W3023133686 hasConcept C77255625 @default.
- W3023133686 hasConcept C86803240 @default.
- W3023133686 hasConcept C95444343 @default.
- W3023133686 hasConceptScore W3023133686C102230213 @default.
- W3023133686 hasConceptScore W3023133686C104317684 @default.
- W3023133686 hasConceptScore W3023133686C107459253 @default.
- W3023133686 hasConceptScore W3023133686C134305767 @default.
- W3023133686 hasConceptScore W3023133686C145103041 @default.
- W3023133686 hasConceptScore W3023133686C1491633281 @default.
- W3023133686 hasConceptScore W3023133686C2910924664 @default.
- W3023133686 hasConceptScore W3023133686C32470452 @default.
- W3023133686 hasConceptScore W3023133686C40767141 @default.
- W3023133686 hasConceptScore W3023133686C54355233 @default.
- W3023133686 hasConceptScore W3023133686C77255625 @default.
- W3023133686 hasConceptScore W3023133686C86803240 @default.
- W3023133686 hasConceptScore W3023133686C95444343 @default.
- W3023133686 hasLocation W30231336861 @default.
- W3023133686 hasOpenAccess W3023133686 @default.
- W3023133686 hasPrimaryLocation W30231336861 @default.
- W3023133686 hasRelatedWork W110265223 @default.
- W3023133686 hasRelatedWork W1971411354 @default.
- W3023133686 hasRelatedWork W1990813571 @default.
- W3023133686 hasRelatedWork W2029533954 @default.
- W3023133686 hasRelatedWork W2077640709 @default.
- W3023133686 hasRelatedWork W2086046223 @default.
- W3023133686 hasRelatedWork W2103540918 @default.
- W3023133686 hasRelatedWork W2115381659 @default.
- W3023133686 hasRelatedWork W2324794509 @default.
- W3023133686 hasRelatedWork W2410560324 @default.
- W3023133686 hasRelatedWork W2461321686 @default.
- W3023133686 hasRelatedWork W2575494223 @default.
- W3023133686 hasRelatedWork W2744405843 @default.
- W3023133686 hasRelatedWork W2791520226 @default.
- W3023133686 hasRelatedWork W2941997115 @default.
- W3023133686 hasRelatedWork W2971391883 @default.
- W3023133686 hasRelatedWork W3001300118 @default.
- W3023133686 hasRelatedWork W3164707679 @default.
- W3023133686 hasRelatedWork W2108712896 @default.
- W3023133686 hasRelatedWork W3196285511 @default.
- W3023133686 isParatext "false" @default.
- W3023133686 isRetracted "false" @default.
- W3023133686 magId "3023133686" @default.
- W3023133686 workType "book-chapter" @default.