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- W3023134448 abstract "Carrots (Daucus carota L.) contain phytochemicals with health-promoting properties including carotenoids, phenolics, polyacetylenes, isocoumarins, terpenes, and sesquiterpenes. Purple carrots also contain anthocyanins, a class of compounds with reported anti-inflammatory activity. Purple carrot was investigated in macrophages and endothelial cells as a novel food capable of modulating inflammatory response to lipopolysaccharide (LPS). A bioactive methanol extract prepared by chromatography reduced inflammatory response in macrophages and endothelial cells as a model of vascular inflammation. Nitric oxide was reduced dose responsively, in addition to mRNA of several pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), and iNOS in macrophage cells. Protein secretion of IL-6 and TNF-α were reduced 77 and 66% in porcine aortic endothelial cells with 6.6 and 13.3 μg/mL of purple carrot from LH-20 respectively. Isolation of active phytonutrients in purple carrot resulted in a bioactive sub-fraction enriched in polyacetylene compounds falcarindiol, falcarindiol 3-acetate, and falcarinol. Isolated polyacetylenes reduced nitric oxide production in macrophage cells by as much as 65% without cytotoxicity. Falcarindiol was the most bioactive polyacteylene. Our results suggest that polyacetylenes, not anthocyanins, in purple carrots are responsible for anti-inflammatory bioactivity." @default.
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- W3023134448 date "2008-03-01" @default.
- W3023134448 modified "2023-09-25" @default.
- W3023134448 title "Purple carrot ( Daucus carota L.) polyacetylenes decrease LPS induced expression of inflammatory proteins in macrophage and endothelial cells" @default.
- W3023134448 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1109.2" @default.
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