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- W3023186009 startingPage "347" @default.
- W3023186009 abstract "This chapter describes the identification of satellite cells as an endogenous source of muscle stem cells that contribute to muscle regeneration and also highlights advances in the regulation of satellite cell activation and self-renewal by biochemical and biophysical components of their niche microenvironment. The satellite cells are described as mononucleated cells with a high nucleus-to-cytoplasm ratio residing in an anatomical compartment between the myofiber basal lamina and its plasma membrane. Satellite cells, like many tissue-resident stem cells, are not consistently proliferating. When individual myofibers are physically dissociated from muscle and placed in culture, satellite cells are activated and migrate off the myofiber to give rise to proliferating myoblasts (progenitors), which eventually form colonies that differentiate and fuse to form multinucleated syncytial cells (myotubes) resembling myofibers. The satellite cells might serve as a resident cell source for mammalian skeletal muscle regeneration after injury. These cells are molecularly characterized by the expression of the paired-box transcription factor Pax7 and the absence of transcription factors that govern further myogenic specialization, such as MyoD and myogenin. In normal adult skeletal muscle, satellite cells are largely mitotically and metabolically quiescent. Following injury or other proliferation signals, satellite cells become “activated” and have strongly upregulated expression of the myogenic regulatory factor Myf5. The satellite cell niche is a membrane-enclosed compartment between the myofiber plasma membrane and the basal lamina that surrounds the myofiber." @default.
- W3023186009 created "2020-05-13" @default.
- W3023186009 creator A5022775890 @default.
- W3023186009 creator A5081185233 @default.
- W3023186009 date "2011-01-01" @default.
- W3023186009 modified "2023-09-25" @default.
- W3023186009 title "Skeletal Muscle Stem Cells" @default.
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