FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023201511> ?p ?o ?g. }

• W3023201511 abstract "Pt(IV) anticancer compounds typically operate as prodrugs that are reduced in the hypoxic environment of cancer cells, losing two axial ligands in the process to generate active Pt(II) species. Here we report the synthesis of two fluorescent Pt(IV) prodrugs of cisplatin in order to image and evaluate the Pt(IV) reduction process in simulated and real biological environments. Treatment of the complexes dissolved in PBS buffer with reducing agents typically encountered in cells, glutathione or ascorbate, afforded a 3- to 5-fold fluorescence turn-on owing to reduction and loss of their fluorescein-based axial ligands, which are quenched when bound to platinum. Both Pt(IV) conjugates displayed moderate cytotoxicity against human cancer cell lines, with IC50 values higher than that of cisplatin. Immunoblotting and DNA flow cytometry analyses of one of the complexes, Pt(IV)FL2, revealed that it damages DNA, causes cell cycle arrest in S or G2/M depending on exposure time, and ultimately triggers apoptotic cell ..." @default.
• W3023201511 created "2020-05-13" @default.
• W3023201511 creator A5026834413 @default.
• W3023201511 creator A5028049515 @default.
• W3023201511 creator A5034625027 @default.
• W3023201511 creator A5038031605 @default.
• W3023201511 creator A5075884507 @default.
• W3023201511 date "2013-08-01" @default.
• W3023201511 modified "2023-09-23" @default.
• W3023201511 title "Synthesis and Characterization of Pt(IV) Fluorescein Conjugates to Investigate Pt(IV) Intracellular Transformations" @default.
• W3023201511 hasPublicationYear "2013" @default.
• W3023201511 type Work @default.
• W3023201511 sameAs 3023201511 @default.
• W3023201511 citedByCount "0" @default.
• W3023201511 crossrefType "journal-article" @default.
• W3023201511 hasAuthorship W3023201511A5026834413 @default.
• W3023201511 hasAuthorship W3023201511A5028049515 @default.
• W3023201511 hasAuthorship W3023201511A5034625027 @default.
• W3023201511 hasAuthorship W3023201511A5038031605 @default.
• W3023201511 hasAuthorship W3023201511A5075884507 @default.
• W3023201511 hasConcept C108215921 @default.
• W3023201511 hasConcept C109316439 @default.
• W3023201511 hasConcept C121332964 @default.
• W3023201511 hasConcept C121608353 @default.
• W3023201511 hasConcept C12554922 @default.
• W3023201511 hasConcept C134306372 @default.
• W3023201511 hasConcept C153911025 @default.
• W3023201511 hasConcept C181199279 @default.
• W3023201511 hasConcept C185592680 @default.
• W3023201511 hasConcept C190283241 @default.
• W3023201511 hasConcept C197336794 @default.
• W3023201511 hasConcept C202751555 @default.
• W3023201511 hasConcept C21951064 @default.
• W3023201511 hasConcept C2776694085 @default.
• W3023201511 hasConcept C2778015030 @default.
• W3023201511 hasConcept C2778239845 @default.
• W3023201511 hasConcept C29537977 @default.
• W3023201511 hasConcept C33923547 @default.
• W3023201511 hasConcept C538909803 @default.
• W3023201511 hasConcept C54355233 @default.
• W3023201511 hasConcept C553184892 @default.
• W3023201511 hasConcept C55493867 @default.
• W3023201511 hasConcept C62520636 @default.
• W3023201511 hasConcept C79879829 @default.
• W3023201511 hasConcept C86803240 @default.
• W3023201511 hasConcept C91881484 @default.
• W3023201511 hasConcept C96232424 @default.
• W3023201511 hasConceptScore W3023201511C108215921 @default.
• W3023201511 hasConceptScore W3023201511C109316439 @default.
• W3023201511 hasConceptScore W3023201511C121332964 @default.
• W3023201511 hasConceptScore W3023201511C121608353 @default.
• W3023201511 hasConceptScore W3023201511C12554922 @default.
• W3023201511 hasConceptScore W3023201511C134306372 @default.
• W3023201511 hasConceptScore W3023201511C153911025 @default.
• W3023201511 hasConceptScore W3023201511C181199279 @default.
• W3023201511 hasConceptScore W3023201511C185592680 @default.
• W3023201511 hasConceptScore W3023201511C190283241 @default.
• W3023201511 hasConceptScore W3023201511C197336794 @default.
• W3023201511 hasConceptScore W3023201511C202751555 @default.
• W3023201511 hasConceptScore W3023201511C21951064 @default.
• W3023201511 hasConceptScore W3023201511C2776694085 @default.
• W3023201511 hasConceptScore W3023201511C2778015030 @default.
• W3023201511 hasConceptScore W3023201511C2778239845 @default.
• W3023201511 hasConceptScore W3023201511C29537977 @default.
• W3023201511 hasConceptScore W3023201511C33923547 @default.
• W3023201511 hasConceptScore W3023201511C538909803 @default.
• W3023201511 hasConceptScore W3023201511C54355233 @default.
• W3023201511 hasConceptScore W3023201511C553184892 @default.
• W3023201511 hasConceptScore W3023201511C55493867 @default.
• W3023201511 hasConceptScore W3023201511C62520636 @default.
• W3023201511 hasConceptScore W3023201511C79879829 @default.
• W3023201511 hasConceptScore W3023201511C86803240 @default.
• W3023201511 hasConceptScore W3023201511C91881484 @default.
• W3023201511 hasConceptScore W3023201511C96232424 @default.
• W3023201511 hasLocation W30232015111 @default.
• W3023201511 hasOpenAccess W3023201511 @default.
• W3023201511 hasPrimaryLocation W30232015111 @default.
• W3023201511 hasRelatedWork W1516412326 @default.
• W3023201511 hasRelatedWork W1964142370 @default.
• W3023201511 hasRelatedWork W1968168357 @default.
• W3023201511 hasRelatedWork W2044874600 @default.
• W3023201511 hasRelatedWork W2051537832 @default.
• W3023201511 hasRelatedWork W2053445834 @default.
• W3023201511 hasRelatedWork W2084123501 @default.
• W3023201511 hasRelatedWork W2145581159 @default.
• W3023201511 hasRelatedWork W2519706887 @default.
• W3023201511 hasRelatedWork W2560622465 @default.
• W3023201511 hasRelatedWork W2586378165 @default.
• W3023201511 hasRelatedWork W2613172782 @default.
• W3023201511 hasRelatedWork W2802424411 @default.
• W3023201511 hasRelatedWork W2884844055 @default.
• W3023201511 hasRelatedWork W2888895093 @default.
• W3023201511 hasRelatedWork W2899859125 @default.
• W3023201511 hasRelatedWork W2939505415 @default.
• W3023201511 hasRelatedWork W2944394200 @default.
• W3023201511 hasRelatedWork W3127788731 @default.
• W3023201511 hasRelatedWork W3200571942 @default.
• W3023201511 isParatext "false" @default.
• W3023201511 isRetracted "false" @default.
• W3023201511 magId "3023201511" @default.

• next