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• W3023218276 abstract "INTRODUCTION AND OBJECTIVE: The data on the association between PDE5i utilization and BCR after RP and PDE5i is mixed. We aimed to provide a better risk assessment based on exposure data. METHODS: Patients completed a PDE5i exposure survey serially after RP in a prospective, quality of life study evaluating men post-RP. PDE5i exposure scores: 0-never, 1-sometimes, 2-regularly, 3-daily. Men who had data on PDE5i use at 3m, 6m, 9m, and 12m in the first year following RP were included in the analysis, thus PDE5i exposure score is the mean of the surveys and ranged from 0-3. The tested predictors of BCR were: age, preoperative PSA, Gleason score (G), surgical margin status (SMS), seminal vesicle involvement (SVI), extra capsular extension (ECE), and lymph node involvement (LNI). Prostate cancer risk categorization was deemed high if: Gleason 8+, LNI+, SMS+ or SVI+. Correlation coefficients and Chi-square was used for univariate analysis and time-to-event (Cox Proportional Hazards) analysis was used for multivariable analysis. RESULTS: Mean age of 647 men was 60.5±7 years. 106 men (16%) had BCR. PDE5i groups are summarized in Figure 1. On univariate analysis, race (black vs white), PSA, and diabetes were associated with BCR (p=0.03 to <0.01). PDE5i score as a continuous variable was not significant (HR 0.96, 95% CI: 0.70-1.33, p=0.82). The highest use PDE5i group (mean score = 2.01 – 3) was not significantly different from the never used group (mean score = 0) (HR 0.95, 95% CI 0.2 – 4.42). On multivariable analysis, race, baseline PSA, and diabetes were associated with BCR (HR 1.55, 1.04, 2.12, respectively). PDE5i dose score was again not a significant predictor of BCR (HR: 0.98, 95% CI: 0.70-1.36). CONCLUSIONS: Using a PDE5i exposure score, PDE5i use is not a risk factor for BCR in RP patients.Source of Funding: None" @default.
• W3023218276 created "2020-05-13" @default.
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• W3023218276 date "2020-04-01" @default.
• W3023218276 modified "2023-09-26" @default.
• W3023218276 title "MP45-08 PHOSPHODIESTERASE TYPE 5 INHIBITOR (PDE5I) USE AFTER RADICAL PROSTATECTOMY (RP) IS NOT ASSOCIATED WITH INCREASED RISK OF BIOCHEMICAL RECURRENCE RISK (BCR)" @default.
• W3023218276 doi "https://doi.org/10.1097/ju.0000000000000900.08" @default.
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